维生素k2对sca3mjd转基因果蝇神经保护作用研究-neuroprotective effect of vitamin k2 on sca 3m jd transgenic drosophila melanogaster.docxVIP

PAGE PAGE 2 1 Vitamin k2 protects against neurodegeneration of the SCA3/MJD transgenic drosophila model ABSTRACT Objective: To confer the influence of vitamin k2 on pathogenesis of SCA3/MJD. Methods: Gmr-GAL4 and Nrv2-GAL4 system SCA3/MJD transgenic Drosophila models were constructed by using the promoter Gmr-GAL4 and Nrv2-GAL4 which drive expanded ataxin-3 proteins expression in cells of the developing eyes and motor neurons, respectively. Then, the above SCA3/MJD transgenic Drosophila models were was raised in vitamin k2. abnormal morphological development of drosophilia melanogaster comp