胃癌彩色多普勒血流分级与mvd、vegf的表达及其相关性分析-expression of mvd and vegf and their correlation analysis in color doppler flow classification of gastric cancer.docxVIP

宁夏医科大学硕士研究生学位论文中文摘要 宁夏医科大学硕士研究生学位论文 中文摘要 II II 分级与淋巴结转移(P=0.000)和血管浸润(P=0.000)有关；CDFI血流分级、MVD值均与 肿瘤大小(P0.05)、浸润深度(P=0.000)有关；VEGF表达与浸润深度(P=0.000)和淋巴 结转移(P0.05)有关，但与肿瘤大小(P0.05)无关。结论 彩色多普勒超声所检测的胃 癌内血流信号与病理微血管密度检测值和血管内皮生长因子表达有较好的相关性，胃癌 术前进行CDFI血流检测，可间接评价肿瘤组织内的血管生成状态，为胃癌的预后评估提 供有益的信息。 关键词 彩色多普勒，微血管密度，血管内皮生长因子，胃癌血流 宁夏医科大学硕士研究生学位论文英文摘要 宁夏医科大学硕士研究生学位论文 英文摘要 III III Research on the Correlation of MVD, Expression of VEGF and Color Doppler Flow Imaging in Patients with Gastric Carcinoma ABSTRACT Objective To explore the correlation between color Doppler flow imaging and microvessel density (MVD), expression of vascular endothelial growth factor (VEGF) in patients with gastric carcinoma. Methods All 60 patients of all periods preoperative underwent CDFI for measuring the blood grades of and normal gastric mucosa tissues. Classified the blood grades according to the flow imaging. GE LOGIQ9 and Siemens-C512-type ultrasound instrument with the 3.5C and 7C-type convex vibration probe were applicated (made in the United States), and the probe frequency range was 2.0-10.0MHz. All the patients were detected matutinus and on an empty stomach post 8 hours. The body position was prostration or lateral position. First, we used 2D (2-Dimensional) ultrasound condition to detect the stomach. The parameters were the location, profile, invading depth of gastric carcinoma, and conditions of both distant and lymph nodes metastasis and vascular invasion. Secondly, we used colour Doppler condition to detect the stomach after we got stable section areas to determine the direction of blood flow, the nature of blood flow and the grade of determination. Moderatly tilting and pressing the probe to make the angle between the beam and the vessel in control of 60 ° or less as far as possible. To ensure the accurace of the data, we must detect both tumor tissues and normal tissues multi-sliced and multi-angled. All the data were measured by the same doctor. MVD and VEGF of corresponding samples were immun