123例经尿道电切术联合化疗治疗膀胱癌疗效分析.docVIP

123例经尿道电切术联合化疗治疗膀胱癌的疗效分析 　　[摘要]目的了解经尿道膀胱肿瘤切除术(transurethral resection of bladder tumor,TURBt)联合不同化疗方式治疗非浸润性膀胱癌和早期浸润性膀胱癌的治疗效果。方法 收集123例膀胱癌患者临床资料,按病理结果分为三组,经TURBt后进行化疗,随访观察肿瘤复发率、实际进展、复发后的治疗手段和3年死亡率。结果 (1)肿瘤复发率:B组在前两年的近期实际复发率明显高于其余两组(p0.05),第3年后B组复发率低于C组(p0.05)。(2)实际进展率:A组3年内的实际进展率明显低于B、C组(p0.05)。C组较B组显著增高(p0.05)。(3)肿瘤复发后治疗方法:A组复发35例,主要采用TURBt术30例(85.71%);B组复发25例,采用TURBt术治疗15例(60.00%),膀胱部分切除术9例(36.00%),膀胱全切3例(12.00%),B组复发采用膀胱部分切除术病例增多;C组复发13例,采用TURBt术4例(30.77%),膀胱部分切除术3例(23.08%),膀胱全切术6例(46.15%),C组,采用膀胱全切术达到46.15%,不过仍然有超过半数的复发病例保留了功能性膀胱。结论 TURBt术联合膀胱灌注化疗对于Ta~1G1~2膀胱癌患者,其疗效确切,值得推荐。对于Ta~1G3膀胱癌,有一定疗效,但近期较易复发。TURBt术联合动脉化疗以及膀胱灌注化疗治疗早期浸润性膀胱癌,不仅可以降低复发率,而且能保留部分患者的膀胱,改善生活质量。 　　[关键词]膀胱肿瘤;经尿道膀胱肿瘤切除术;动脉灌注;膀胱灌注化疗 　　[中图分类号]R737.14[文献标识码]A [文章编号] 1005-0515(2010)-7-0012-02 　　 　　123cases retrospectively analyzed:the effectiveness of transurethla resection 　　of bladder tumour followed by chemiotherapy 　　CHEN wei-guo1,XV bin-xian1,Gu Hong Jun2 　　(1 No. 100 Hospital of Peoples Liberation Army, Suzhou215000, china ; 　　2 The first Affiliated Hospital of Suzhou University ,Suzhou215006, china) 　　[Abstract]ObjectiveTo asses the effectiveness of treating bladder canner with transurethral resction (TUR-BT) followed by chemiontherapy. Method123 patients with bladder cancer treated by TUR-BT with chemioth analyzed.three groups were divied by pathological type.Clinicopathologic parameters,recurrence and progression rates,treatment methods of recurrence and mortality of three years were determined,and compared. Results1. Recurrence rates:Recurrence rates of B group was more than that of others(p0.05) in two years and then recurrence rates of B group was less than that of C groups (p0.05).2.Progression patiens in B rates:Progression rates of A group was more than thant of others(p0.05).Recurrence rates of C group was more than that of B group (P0.05).3.Treatment methods of recurrence:35patien of A group recurred.Of those 30 patiens underwent TUR-BT again 25 patiens in B group recurred,of w