A型肉毒毒素治疗局灶型肌张力障碍疗效及影响因素分析.docVIP

A型肉毒毒素治疗局灶型肌张力障碍疗效及影响因素分析 　　[摘要] 目的 探讨A型肉毒毒素治疗眼睑痉挛（BS）、面肌痉挛（HFS）和Meige综合征的疗效及影响因素与疗效的关系。 方法 前瞻性收集在我院神经内科门诊就诊、自愿接受A型肉毒毒素局部注射治疗的HFS、BS和Meige综合征患者60例，记录其一般情况、发病年龄、病程、治疗前后的Albert和Cohen评分及效果维持时间。数据录入SPSS20.0软件进行Pearson直线相关分析。 结果 多因素回归分析显示，BS患者效果维持时间和病程呈负相关性（r=-0.677，P=0.037）；单因素分析显示，HFS患者治疗前Albert和Cohen评分越低，有效率越高（P0.05）。 结论 BS患者病程越短，疗效越好；HFS患者症状越轻，治疗有效率越高。 　　[关键词] 面肌痉挛；眼睑痉挛；Meige综合征；A型肉毒毒素 　　[中图分类号] R746.3 [文献标识码] A [文章编号] 1673-9701（2015）26-0019-04 　　Analysis of efficacy and influence factors of type A botulinum toxin in treatment of focal dystonia 　　CHEN Ling XU Zhong SHANG Qunzhu BI Xiumei AI Qinglong 　　Department of Neurology， First Affiliated Hospital of Kunming Medical University， Kunming 650032， China 　　[Abstract] Objective To investigate the efficacy and the correlation between the efficacy and the influence factors of type A botulinum toxin in the treatment of blepharospasm （BS）， hemifacial spasm （HFS） and Meige syndrome. Methods Sixty patients with HFS， BS and Meige syndrome who were treated and voluntarily accepted local injection of type A botulinum toxin in the neurology outpatient department of our hospital were collected retrospectively， and their general conditions， age of onset， courses of disease， pretreatment and posttreatment albert and cohen scores and effect duration time were recorded. SPSS20.0 was used for data entry and Pearson linear correlation analysis. Results Multivariate regression analysis showed that the BS patients effect duration time and course of disease were negatively correlated （r=-0.677，P=0.037）. Univariate analysis showed that the lower the HFS patients pretreatment Albert and Cohen scores were， the effective rate was higher（P0.05）. Conclusion The BS patients course of disease is shorter， The efficacy is better. The HFS patients symptoms are lighter， The effective treatment rate is higher. 　　[Key words] Hemifacial spasm； Blepharospasm； Meige syndrome； Type A Botulinum toxin 　　肌张力障碍（dystonia）是一种不自主、持续性的肌肉收缩引起的扭曲、重复运动或姿势异常