滤泡树突状细胞(FDC专题汇报.pptxVIP

Follicular dendritic cells;BACKGROUND;Within the lymph node environment, there is a heterogeneous population of stromal cells that are characterized, in part, by their differential expression of CD31 (also known as PECAM1) and podoplanin (also known as gp38 in mice and gp36 in humans). The five major stromal cell types that can be distinguished on the basis of their morphology and function are fibroblastic reticular cells (FRCs), marginal reticular cells (MRCs), lymphatic endothelial cells (LECs), blood endothelial cells (BECs) and FDCs. ; FDCs have received little attention and in vitro studies are challenging because FDCs are rare and fragile. an understanding of FDCs is critical to an understanding of GCs, B lymphocyte maturation, and optimal Ab responses that are critical to effective vaccination. GCs are a fundamental feature of the immune system and presentation of FDC-Ags to B cells has potential applications. Rapid responses may be crucial for protecting people traveling in areas with endemic infections, from biological warfare, or rapidly spreading epidemics. The ability of FDCs to productively present Ag to B cells should advance the development of new mAbs including human mAbs. On the other hand, FDC-ICs probably promote autoimmune diseases.;Timeline of major discoveries in the FDC field; Basic overview of lymph node and FDC ;Follicular dendritic cells (FDCs) are a unique population of cells that is essential for efficient germinal centre (GC) formation and for the production of high-affinity antibodies1 . They are centrally located within B cell follicles in secondary lymphoid organs and, they develop from perivascular precursors of stromal cell origin that are seeded throughout the body. FDC maturation requires lymphotoxin and tumour necrosis factor (TNF) signalling through B cells, and the disruption of these pathways leads to the loss of FDCs. ;In the spleen and lymph nodes, FDCs are just one stromal cell type within a network of stromal cells. A