2型糖尿病与骨质疏松关系探讨.docVIP

2型糖尿病与骨质疏松关系的探讨 　　[摘要] 目的 探?2型糖尿病（T2DM）患者与骨质疏松（osteo porosis，OP）的相关性。 方法 选取2015年9月～2017年2月我院收治的180例2型糖尿病患者，将90例2型糖尿病患者血糖控制达标设为A组；另外90例2型糖尿病患者空腹（血糖≥7.0mmoL/L）及餐后2小时血糖（血糖≥10.0mmoL/L）均升高为B组。另选择我院同期健康体检者90例作为对照组，采用美国GDR-2000型Hologac Sahara超声骨密度仪测量跟骨骨密度。测定全部受试者均测量身高、体重，计算体重指数（BMI）。过夜空腹12h以上，次日晨采静脉血，检测糖化血红蛋白（HbAlc）、血磷、尿钙、血钙、血镁、甲状旁腺激素（PTH）、25羟维生素D3（25（OH）D3）及碱性磷酸酶（ALP）等临床生化指标。 结果 A组尿钙、血钙、血镁、PTH、25（OH）D3等指标与对照组比较差异有统计学意义（P0.05）；B组尿钙、血钙、血镁、PTH、25（OH）D3、ALP等指标与对照组比较差异有统计学意义（P0.05）；B组尿钙明显高于A组，而血镁、25（OH）D3、ALP等指标明显低于A组，且比较差异有统计学意义（P0.05）；骨质疏松组患者HbAlc、PTH、糖尿病病程等指标均明显高于骨量减低组和骨密度正常组，且比较差异军有统计学意义（P0.05）；病程、HbAlc、PTH是糖尿病患者骨密度降低的危险因素。 结论 血糖控制未达标T2DM患者骨密度水平低于血糖控制达标2型糖尿病患者，T2DM与OP二者有相关性。病程、HbAlc、PTH是影响T2DM患者骨密度水平的因素。 　　[关键词] 2型糖尿病；骨质疏松；骨密度 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 2095-0616（2017）12-192-04 　　Relationship between type 2 diabetes and osteoporosis 　　DU Lingchao GUO Caixia RU Zhicheng 　　Internal Medicine Ward II，Dongguan Eighth Peoples Hospital，Dongguan 523325，China 　　[Abstract] Objective To investigate the correlation between osteoporosis（OP） and type 2 diabetes mellitus （T2DM）. Methods 180 patients with type 2 diabetes mellitus in our hospital from January 2015 to February 2017 were selected.90 patients with type 2 diabetes mellitus were divided into group A，and 90 patients with type 2 diabetes with fasting（blood glucose≥7.0mmol/L） and 2 hours postprandial blood glucose （blood glucose≥10.0mmol/L） were divided into group B.And 90 cases of healthy physical examination in our hospital were selected as the control group.The bone mineral density of calcaneus was measured by American GDR-2000 Hologac Sahara Ultrasound Bone Minimetry.All subjects were measured for height，body weight，and body mass index （BMI）.（HbAlc），blood phosphorus，urinary calcium，serum calcium，blood magnesium，parathyroid hormone（PTH），25-hydroxy vitamin D3（25（OH）D3） were measured on the morning fasting for more than 12 hours.And alkaline phosphatase（ALP） and other clinical biochemical indicators. Results The le