146株金黄色葡萄球菌耐药性监测与分析.docVIP

146株金黄色葡萄球菌的耐药性监测与分析 　　【摘要】 目的：调查金黄色葡萄球菌对15种抗菌药物的敏感性。方法：收集2015年1月-2016年9月以来，临床分离的146株金黄色葡萄球菌，采用美国BD公司生产的PhoenixTM-100细菌鉴定/药敏系统检测15种抗菌药物对分离菌的敏感性，数据分析采用WHONET5.6软件。结果：耐甲氧西林金黄色葡萄球菌（MRSA）占金黄色葡萄球菌的比例为24.7%。金黄色葡萄球菌对15种常用抗菌药物总耐药率依次为氨苄西林96.6%、青霉素95.9%、红霉素72.6%、克林霉素43.2%、阿莫西林/克拉维酸25.0%、复方新诺明及苯唑西林24.7%、妥布霉素21.2%、庆大霉素20.5%、环丙沙星17.1%；来源不同部位的标本分离的金黄色葡萄球菌对同一种抗菌药物的耐药率差异显著。结论：临床医生在治疗金黄色葡萄球菌引起的感染的过程中，应根据不同感染部位参考耐药性监测，给予合适的抗菌药物，临床上一旦检出MRSA，微生物室要根据NCCLS的有关规定修订药敏报告。 　　【关键词】 金黄色葡萄球菌； 药敏试验； 耐药性； MRSA 　　doi：10.14033/ki.cfmr.2017.30.035 文献标识码 B 文章编号 1674-6805（2017）30-0069-03 　　Drug-resistance Monitoring and Analysis of 146 Strains of Staphylococcus Aureus/GUO Li-na.//Chinese and Foreign Medical Research，2017，15（30）：69-71 　　【Abstract】 Objective：To investigate the sensitivity of staphylococcus aureus（S.aureus） to 15 kinds of antibacterial drugs.Method：From January 2015 to September 2016，146 strains of S.aureus were selected，clinical separation of trace broth dilution method detection of 15 kinds of antimicrobial agents for sensibility of isolated bacteria.WHONET5.6 software was used to analyze the data.Result：Methicillin-resistant S.aureus（MRSA） accounted for 24.7% of S.aureus，the drug-resistance rate of S.aureus to Am-picillin was 96.6%，to Penicillin was 95.9%，to Erythromycin was 72.6%，to Clindamycin was 43.2%，to Amoxicillin/Clavulanic Acid was 25.0%，to Compound Sulfamethoxazole and Oxacillin were 24.7%，to Tobramycin was 21.2%，to Gentamicin was 20.5%，to Ciprofloxacin was 17.1%.Specimens from different parts of the source separation of S.aureus to the same kind of antimicrobial resistance difference is significant.Conclusion：Clinicians in the treatment of infections caused by S.aureus，shall according to different infection site reference drug resistance surveillance，to appropriate antimicrobial agents，once the clinical detection of MRSA，microbial chamber shall be revised according to NCCLS the relevant provisions of the drug susceptibility reports. 　　【Key words】 Staphylococcus aureus；