121例呼吸系统疾病患者血清淀粉样蛋白A测定结果分析及临床意义.docVIP

121例呼吸系统疾病患者血清淀粉样蛋白A测定结果的分析及临床意义 　　昆明医学院第一附属医院,云南 昆明 650032 　　 　　【摘 要】:目的:分析呼吸系统疾病患者血清淀粉样蛋白A(SAA)的测定结果及临床意义#65377;方法:采用终点散射比浊法检测SAA和高敏C反应蛋白(hsCRP)水平#65377;结果:121例患者血清SAA和hsCRP水平都比对照组有明显升高(P0.01);且SAA治疗前后有显著性差异(P0.01,hsCRP也有显著性差异(P0.01), 血清SAA与hsCRP水平呈正相关(治疗前:r=0.59;治疗后:r=0.67)#65377;结论:血清SAA的检测有助于监测呼吸道患者的病程,评估患者预后和疗效#65377; 　　 【关键词】:呼吸系统疾病;血清淀粉样蛋白A;高敏C反应蛋白 　　 【中图分类号】R56;R927.2【文献标识码】 B 【文章编号】1007-8517(2009)03(上)-0079-02 　　 　　The analysis determination the results of 121 cases of respiratory illness in patients with serum amyloid protein 　　 A and clinical significance 　　Shao-Tianbo1 Yu-Liping2 He-Zengping1 　　( 1) Clinical laboratory, 　　2)Department of pediatrics,Kunming Medical College Hospital of the First Affiliated Hospital, Kunming, Yunnan 650032) 　　 　　Abstract:Objective Analysis of the results of respiratory diseases in patients with serum amyloid A (SAA) determination and clinical significance . Methods The use of endpoint nephelometry assay SAA and high-sensitivity C-reactive protein (hsCRP) level. Results 121 cases of patients with SAA and hsCRP levels are significantly higher than the control group (P 0.01); and SAA before and after treatment were significantly different (P 0.01, hsCRP has also significantly different (P 0.01), serum SAA and hsCRP level was a positive correlation (before treatment:r = 0.59; after treatment:r = 0.67). Conclusion Detection of SAA in serum contribute to the monitoring of patients with respiratory tract disease, assess prognosis and efficacy of patients. 　　Key words:Respiratory diseases; Serum amyloid A; High-sensitivity C-reactive protein 　　 　　 急性时相反应蛋白(acute phase reactants, APR)是在机体发生感染#65380;炎症#65380;心肌梗塞#65380;肿瘤等情况下,血浆浓度发生显著变化的一类蛋白质,其改变与多种疾病病变有关[1]#65377;近年来,SAA作为一种急性时相反应蛋白已被用于临床[2]#65377;但研究和报道最多的是在心血管方面,在呼吸系统疾病中变化的文献尚不多见#65377;为此,我们对我院呼吸科住院的121例呼吸系统患者诊治过程中血清淀粉样蛋白A(SAA)的检测结果进行了分析,旨在探讨血清淀粉样蛋白A(SAA)在呼吸系统疾病诊治中的价值,并与血清hsCRP的相关性进行分析#65377; 　　 　　1 材料与方法 　　 　　1.1 一般资料 本院呼吸科住院患者121例,男76例,女45例,年龄15~88岁,其中61~88