ω―3多不饱和脂肪酸对脓毒症患者氧化应激及免疫状态影响研究.docVIP

ω―3多不饱和脂肪酸对脓毒症患者氧化应激及免疫状态影响研究 　　【摘要】 目的：探究ω-3多不饱和脂肪酸对脓毒症患者氧化应激及免疫状态的影响。方法：将患者按随机数字表法分为观察组和对照组，每组各30例。两组患者均接受等氮、等热量全合一营养液肠外营养支持以及相应的常规治疗，连续7 d。其中对照组脂肪由20%中长链脂肪乳制剂提供，观察组脂肪由ω-3多不饱和脂肪酸+20%中长链脂肪乳提供。观察比较两组治疗前后氧化应激反应、免疫功能等相关指标的变化情况，并做出分析总结。结果：观察组在治疗后第8天炎症反应及免疫指标较对照组均改善明显（P0.05），血浆脂质过氧化物LOP、血清MDA在治疗后显著下降，血清谷胱甘肽CSH上升（P0.05），氧化应激反应得到了有效控制。结论：ω-3 PUFAs可改善脓毒症患者免疫功能，减轻炎症反应，有效控制氧化应激反应的发生。 　　【关键词】 ω-3多不饱和脂肪酸； 脓毒症； 免疫状态； 氧化应激； 影响 　　Oxidative Stress and Immune Status Impact Study on Sepsis Patients by ω-3 Polyunsaturated Fatty Acids/ZHANG Xian-hua， WANG Bin.//Medical Innovation of China，2015，12（15）：007-009 　　【Abstract】 Objective：To explore the oxidative stress and immune status impact study on sepsis patients byω-3polyunsaturated fatty acids.Method：Patients were randomly divided into observation group and control group， 30 cases in each group.Two groups of patients were accepted nutrients such as nitrogen， such as heat all-in-one parenteral nutrition support and the corresponding conventional treatment， continuous for 7 d.Which controls provided by the long chain fatty milk 20%， observation group by omega-3 polyunsaturated fatty acid + 20% long chain fatty milk.Before and after treatment oxidative stress response and immune function changes of the related indexes were compared of the two groups， and make analysis summary.Result：The observation group in the eighth day after the treatment of inflammation and immune indexes improved than the control group significantly （P0.05）， oxygen stress index， plasma lipid peroxides LOP， serum MDA declined significantly，serum glutathione GSH was increased after treatment （P0.05）， oxidative stress response to effective control.Conclusion：Omega-3 PUFAs can improve the immune function of patients with sepsis， reduce inflammation， effective control of oxidative stress reaction. 　　【Key words】 ω-3 polyunsaturated fatty acids； Sepsis； Immune status； Oxidative stress； Impact 　　First-author’s address：Shenzhen Second People’s Hospital， Shenzhen 51800