Pre―S1S2抗原检测在乙型肝炎临床诊断中作用及价值.docVIP

Pre―S1S2抗原检测在乙型肝炎临床诊断中作用及价值 　　[摘要] 目的 探讨Pre-S1、S2抗原检测在乙型肝炎临床诊断中的作用及价值。 方法 回顾性分析2010年6月～ 2012年6月笔者所在医院就诊的Pre-S1、Pre-S2抗原检测为阳性和两项检测结果均为阳性的患者各50例临床资料，根据检查方法分为Pre-S1组、Pre-S2组与观察组。所有患者均进行HBV-DNA含量检测，1.0×103 copiese/mL即为阳性，比较三组患者HBV-DNA检出率。 结果 观察组HBV-DNA检出率为94.0%，明显高于Pre-S1组（86.0%）与Pre-S2组（80.0%），差异具有统计学意义（P0.05）。 结论 临床上检测Pre-S1、S2抗原的含量可以为乙肝病毒的复制提供可靠地依据，如果在同一个样本中检测出Pre-S1、S2两种抗原，则可以说明乙肝病毒已经复制。 　　[关键词] 乙型肝炎病毒；Pre-S1抗原；Pre-S2抗原；复制 　　[中图分类号] R512.6 [文献标识码] B [文章编号] 2095-0616（2013）14-119-02 　　Clinical diagnosis value and function of combined detection of Pre-S1 and Pre-S2 antigen in patients with hepatitis B 　　LI Qingfeng BI Lei SHANG Pengcheng WANG Bo JIAN Ling 　　Public Health Clinical Medical Center in Chengdu City，Chengdu 610066，China 　　[Abstract] Objective To study the Clinical diagnosis value and function of combined detection of Pre-S1 and Pre-S2 antigen in patients with hepatitis B. Methods The clinical data of Pre-S1 positive 50 patients， Pre-S2 positive 50 patients and two antigens positive 50 patients in our hospital from June 2010 to June 2012 were chosen and retrospectively analyzed. All patients were divided into the Pre-S1 group （50 cases）， Pre-S2 group（50 cases） and experiment group （50 cases） according to the detection method. All the patients were given HBV-DNA content detection，of which more than 1×103 copiese/mL was positive.The HBV-DNA detection rates of three groups were compared. Results The HBV-DNA detection rate of experiment group was 94%， significantly higher than that of Pre-S1 group 86.0% and Pre-S2 group 80.0%.The differences were statistically significant（P0.05）. Conclusion Determination of Pre-S1， S2 antigen can provide reliable basis for HBV-DNA replication in the clinical，If Pre-S1 and S2 antigen is detected in the same sample，that can explain the hepatitis B virus has been copied. 　　[Key words] Hepatitis B virus；Pre-S1 antigen；Pre-S2 antigen；Replication 　　乙型肝炎是由乙型肝炎病毒（hepatitis B virus，HBV）感染所致，其是一种全球性的传染病，严重威胁着人类的健康，世界各国皆制定了防止HBV传播