NT―proBNP水平对非ST段抬高型急性冠脉综合征危险分层价值研究.docVIP

NT―proBNP水平对非ST段抬高型急性冠脉综合征危险分层价值研究 　　[摘要] 目的 探讨血液中N末端B型利钠肽原（NT-proBNP）对非ST段抬高型急性冠状动脉综合征（NSTE-ACS）危险分层的价值。 方法 选取2012年1月～2013年12月间我科94例NSTE-ACS患者分为高危NSTE-ACS组52例（高危UAP22例，NSTEMI30例）和非高危NSTE-ACS组42例[低危UAP20例，中危UAP 22例]；将具有胸痛症状且经冠状动脉CT造影（CCTA）证实为阴性的患者为对照组，共38例。入院后即刻采集静脉血同时检测NT-proBNP、高敏肌钙蛋白T（hs-cTnT）浓度，比较各组间NT-proBNP、hs-cTnT浓度的变化，并分析其相关性。 结果 高危NSTE-ACS组NT-proBNP、hs-cTnT浓度均高于非高危NSTE-ACS组，差异有统计学意义（P0.01），经Pearson直线相关分析，高危NSTE-ACS组NT-proBNP浓度与hs-cTnT浓度呈正相关（r=0.92，P0.001）；非高危NSTE-ACS组NT-proBNP浓度与hs-cTnT浓度亦呈正相关（r=0.83，P0.001）。 结论 NT-proBNP是心肌缺血损伤的可靠指标，可作为NSTE-ACS危险分层的依据。 　　[关键词] 非ST段抬高型急性冠状动脉综合征；N末端B型利钠肽原；高敏心肌肌钙蛋白；冠心病；危险分层 　　[中图分类号] R541.4 [文献标识码] B [文章编号] 1673-9701（2016）16-0024-03 　　[Abstract] Objective To study of the N-terminal pro-brain B-type natriuretic peptide（NT-proBNP）in the risk stratification value of non-ST segment elevation acute coronary syndrome（NSTE-ACS ACS）. Methods 94 patients with NSTE-ACS in January 2012 to December 2013 were divided into high-risk NSTE-ACS group （52 patients） including 22 patients with high-risk unstable angina pectoris （high-risk UAP），30 patients with non-ST segment elevation acute myocardial infarction（NSTEMI），and non-high-risk NSTE-ACS group（42 patients） including 20 patients with low-risk UAP and 22 patients with middle-risk UAP；38 patients with noncardiac chest pain by coronary computed tomography angiography（CCTA） was control group. By collecting venous blood and detecting concentration of NT-proBNP and high sensitive troponin T（hs-cTnT） of patients with NSTE-ACS， concentration of NT-proBNP and hs-cTnT of patients with NSTE-ACS in each group was compared and their correlation was analyzed. Results Concentration of NT-proBNP and hs-cTnT was higher in high-risk NSTE-ACS group than in non-high-risk NSTE-ACS group（P0.001）； concentration of NT-proBNP positively correlated with hs-cTnT level in high-risk NSTE-ACS group（r=0.92，P0.001） by Pearson rectilinear correlation analysis，so in non-high-risk NSTE-ACS group（r=0.83，P0.001）. Concl