HMGB1在评价类风湿关节炎疾病活动度中意义及与RA―ILD关系初探.docVIP

HMGB1在评价类风湿关节炎疾病活动度中意义及与RA―ILD关系初探 　　【摘 要】目的：探讨血清高迁移率族蛋白1在类风湿关节炎治疗监测和对类风湿关节炎相关性肺间质病变早期诊断的临床价值。方法：搜集已确诊的类风湿关节炎患者（缓解期25例，活动期56例）血液 　　标本，测定血清高迁移率族蛋白1水平，并对红细胞沉降率、C-反应蛋白和类风湿因子进行同步检测，同期健康体检者25例作为正常对照组。结果：活动期患者各检测指标水平高于缓解期，缓解期高于正常对照组。类风湿关节炎患者高迁移率族蛋白1水平与红细胞沉降率、C-反应蛋白、类风湿因子呈正相关 　　（P 0.01）。活动期的单纯类风湿关节炎患者与类风湿关节炎相关性肺间质病变患者高迁移率族蛋白1水平比较，差异有统计学意义（P 0.05）。结论：血清高迁移率族蛋白1在类风湿关节炎患者表达升高，并与病情活动度有一定相关性，在类风湿关节炎相关性肺间质病变早期诊断方面具有临床研究价值。 　　【关键词】 关节炎，类风湿；高迁移率族蛋白1；疾病活动度；肺间质病变；血清 　　doi：10.3969/j.issn.2095-4174.2015.04.002 　　Significance of HMGB1 in the Evaluation of Disease Activity of Rheumatoid Arthritis 　　and Its Relationship with RA-ILD 　　XU Li，LIU Jing 　　【ABSTRACT】Objective：To investigate the clinical value of high mobility group box 1 protein in monitoring rheumatoid arthritis during treatment and the early diagnosis of rheumatoid arthritis-related interstitial lung disease.Methods：Blood samples of diagnosed patients with rheumatoid arthritis（25 cases of remission， 　　56 cases in active stage）were collected to determinate the level of high mobility group box 1 protein，C-reactive protein and rheumatoid factor.The healthy examinees 25 cases in the same period were treated as ones in the normal control group.Results：All the index levels in patients at active stage were higher than those in patients at the remission stage，and these levels in patients at the remission stage were higher than those in patients of the normal control group.The level of high mobility group box 1 protein in patients with rheumatoid arthritis had a positive correlation with erythrocyte sedimentation rate，C-reactive protein and rheumatoid factor（P 0.01）.The difference of high mobility group box 1 protein between active-stage patients of rheumatoid arthritis and patients with interstitial lung disease associated with rheumatoid arthritis was statistically significant（P 0.05）.Conclusion：The increase of high mobility group box 1 protein expression in patients with rheumatoid arthritis has a certain degree of