C―反应蛋白与血清白细胞介素―18检验对急性脑梗死意义研究.docVIP

C―反应蛋白与血清白细胞介素―18检验对急性脑梗死意义研究 　　[摘要] 目的 探索研究急性脑梗死患者C- 反应蛋白与血清白细胞介素-18 （IL-18）两项指标的临床研究意义。 方法 整群选取2014年6月―2015年6月住院治疗的急性脑梗死患者103例（试验组）和门诊体检结果健康者98例（对照组），检测其C- 反应蛋白和白细胞介素-18指标，结果进行统计分析。 结果 同对照组健康者对比，试验组急性脑梗死患者的血清白细胞介素 -18和C- 反应蛋白的检验指标显著增高（P0.05），试验组患者不同时间检验结果相互比较，发病第3日两项指标结果均显著高于其他时间值（P0.05）；试验组中脑梗死程度高的患者，其指标值显著高于程度较轻患者的指标值（P0.05）。 结论 通过检测C- 反应蛋白和血清白细胞介素 -18指标，可对急性脑梗死患者疾病严重程度进行评价和其预后进行参考。 　　[Abstract] Objective To explore the clinical significance of C-reactive protein and serum interleukin-18 these two indicators in acute cerebral infarction. Methods The measurement of C-reactive protein and serum interleukin-18 levels was performed in 103 cases with acute cerebral infarction （test group） underwent inpatient treatment from June 2014 to June 2015 and 98 healthy controls underwent physical examination in the outpatient during the same period and had normal results （control group）. The results of the measurement were analyzed statistically. Results The C-reactive protein and serum interleukin-18 levels were much higher in the test group than those in the control group（P0.05）. The C-reactive protein and serum interleukin-18 levels in the test group on the third day after the onset were the highest compared with those at other times（P0.05）. In the test group， the C-reactive protein and serum interleukin-18 levels were much higher in the patients with more severe acute cerebral infarction than in those with milder acute cerebral infarction（P0.05）. Conclusion The measurement results of C-reactive protein and serum interleukin-18 levels can provide a reference for the evaluation of the severity and prognosis of acute cerebral infarction. 　　[Key words] C-reactive protein； Serum interleukin-18； Acute cerebral infarction 　　脑梗死（cerebral infarction）称缺血性卒中，是指各种原因所致脑部血液供应障碍，导致局部脑组织缺血、缺氧性坏死，而出现相应神经功能缺损的临床综合征[1]。C- 反应蛋白和血清白细胞介素-18为炎症性反应的标志物之一。有关文献指出[2]，由于社会竞争压力日趋加重，我国人群急性脑梗死患病率不断增加，医务工作者应重视深入研究此病的发病机制和诊断治疗，制定出更准确、更快速的诊断治疗方案。该研究整群选取2014年6月―2015年6月该院收治的103例急性脑梗死患者为试验组和98例门诊体检结果健康者