HIF1aCOX2在直肠癌组织中表达及其临床意义.docVIP

HIF1aCOX2在直肠癌组织中表达及其临床意义 　　摘 要 目的：探讨HIF-1a、COX-2在直肠癌组织中的表达及其临床意义。方法：收集手术切除的直肠癌组织标本69例作为研究组，同期收集癌旁正常直肠组织（直肠癌边缘外6 cm）标本69例作为对照组，采用免疫组化方法检测HIF-1a、COX-2表达，比较两组HIF-1a、COX-2阳性表达率，分析两者与直肠癌临床病理因素的关系。结果：研究组HIF-1a、COX-2阳性表达率均明显高于对照组（P0.05）；HIF-1a、COX-2表达与直肠癌Ducks分期、组织分化程度和淋巴结转移紧密相关，Ducks分期越高、组织分化程度越低，合并淋巴结转移者直肠癌组织HIF-1a、COX-2阳性表达率显著增高（P0.05）。结论：HIF-1a、COX-2在直肠癌组织中的高表达与临床分期、组织分化程度和淋巴结转移等临床病理特征显著相关。 　　关键词 HIF-1a COX-2 直肠癌 　　中图分类号：R735.37 文献标识码：A 文章编号：1006-1533（2015）19-0050-03 　　The expression of HIF-1α and COX-2 in colorectal cancer tissue and its clinical significance * 　　WEI Fenlan**， WANG Shengde 　　（Department of Oncology， The People’s Hospital of Yingtan City， Jiangxi Province， Yingtan 335000， China） 　　ABSTRACT Objective： To investigate the expression of HIF-1a and COX-2 in colorectal cancer tissue and its clinical significance. Methods： Specimens from both the colorectal cancer tissue of operation resection and the adjacent normal rectal tissue （the edge of rectal cancer6 cm） were selected as a study group and a control group with 69 cases each， respectively. The expression of both HIF-1a and COX-2 was detected by an immunohistochemical method and the positive rate of their expression was compared between two groups. The relationship between their expression and the clinical pathological factors of colorectal cancer were analyzed. Results： The positive rate of HIF-1a and COX-2 expression was significantly higher in the study group than in the control group （P0.05） and their expression was closely related to Ducks staging， differentiation degree and lymph node metastasis. The higher Ducks stage was， the lower the differentiation degree was， and the positive rate of their expression in the colorectal cancer tissue complicated with lymph node metastasis was significantly increased （P0.05）. Conclusion： The over expression of HIF-1a and COX-2 in colorectal cancer tissue is significantly correlated with the clinical stage， tissue differentiation degree and lymph node met