3种方案治疗急性重度酒精中毒的成本―效果分析.docVIP

3种方案治疗急性重度酒精中毒的成本―效果分析 　　doi：10.3969/j.issn.1007-614x.2014.11.63 　　摘 要 目的：评价3种方案治疗急性重度酒精中毒的疗效及经济学效果。方法：将90例急性重度酒精中毒的患者随机分成A、B、C三组，每组30例，A组给予纳洛酮治疗，B组给予纳洛酮加丹参治疗，C组给予纳洛酮加醒脑静治疗，对临床疗效进行观察，并进行药物经济学分析。结果：A、B、C组的总有效率分别为76.67%，93.33%，96.67%，成本-效果比分别为1.45，0.57，1.70；增量成本-效果比，与B组方案比较，A组-3.45，C组33.38。结论：B组方案较佳。 　　关键词 药物经济学 急性重度酒精中毒 纳洛酮 丹参 　　Analysis of cost-effect of three kinds of solutions in the treatment of acute severe alcoholism 　　Guo Huachun1，Zhang Xiaoling1，Zeng Kunqing2，Lei Jingling1 　　The Community Health Service Centre of Tianyuan Street，Tianhe District，Guangzhou City，Guangdong 5103601 　　The Peoples Hospital of Tianhe District，Guangzhou City，Guangdong 5106602 　　Abstract Objective：To evaluate the curative effect and economic effect of three kinds of solutions in the treatment of acute severe alcoholism.Methods：90 patients with acute severe alcoholism were randomly divided into A，B，C group with 30 cases in each.The A group was treated with naloxone，the B group was treated with naloxone plus salvia miltiorrhiza，the C group was treated with naloxone and Xing Nao Jing.The clinical therapeutic effect was observed，and we took pharmacoeconomics analysis.Results：The total effective rates of A，B，C group were 76.67%，93.33%，96.67% respectively，the cost-effect ratios were 1.45，0.57，1.70 respectively；for the incremental cost-effect ratio，compared with the B group，A group was -3.45，C group was 33.38.Conclusion：The scheme of B Group is better. 　　Key words Pharmacoeconomics analysis；Acute severe alcoholism；Naloxone；Salvia miltiorrhiza 　　随着人们物质生活水平的不断提高，酗酒成为一种普遍的社会现象，由于酗酒而导致的急性酒精中毒也逐年上升，并且成为急诊内科的常见病及危重病。对于急性酒精中毒，如不能及时有效救治，严重时可导致患者死亡。笔者通过经济学原理和方法，对治疗急性重度酒精中毒的3种方案进行成本-效果分析，旨在为用药提供科学客观的依据。 　　资料与方法 　　2010年7月-2011年6月收治急性重度酒精中毒患者90例，符合有关文献的诊断标准，排除化学气体、镇静安眠药中毒，颅脑损伤、脑血管意外、糖尿病昏迷，及精神病和癫痫所致的昏迷[1]。随机分成A、B、C三组。A组男23例，女7例，年龄22～60岁，平均37.6岁，饮酒量（550±115）ml，昏睡28例，昏迷2例，出现中毒症状至就诊时间（32±10）分钟。B组男21例，女9例，年龄20～59岁，平均37.3岁，饮酒量（540±100）ml，昏睡27例，昏迷3例，出现中毒症状至就诊时间（30±10）分钟。C组男22例，女8例，年龄21～61岁，平均37.5岁，