不同工艺白金胶囊对慢性不可预知应激所致小鼠抑郁症影响.docVIP

不同工艺白金胶囊对慢性不可预知应激所致小鼠抑郁症的影响 　　摘要：目的 评价不同工艺制备的白金胶囊治疗慢性不可预知应激所致小鼠抑郁症的药效。方法 采用慢性不可预知应激制备小鼠抑郁模型。实验小鼠按体质量随机分为模型组、阳性药组、工艺品1（传统工艺）大剂量组、工艺品1小剂量组、工艺品2（精制工艺）大剂量组、工艺品2小剂量组，各药物组小鼠予相应剂量灌胃给药。通过测定小鼠游泳不动时间、悬尾不动时间两个行为学指标考察白金胶囊传统工艺和精制工艺的抗抑郁作用；通过测定小鼠自主活动和体质量考察受试药物是否具有中枢兴奋性或改变动物机体的机能状态的作用。结果 模型组和工艺品2大、小剂量组小鼠游泳不动时间分别为（138.27±40.70）s、（100.01±34.75）s、（88.15±30.62）s，差异有统计学意义（P0.01）；模型组和工艺品2小剂量组小鼠自主活动次数分别为（668±19）次、（705±24）次，差异有统计学意义（P0.01）；模型组和工艺品1大剂量组体质量分别为（28.14±1.25）g、（26.43±2.58）g，差异有统计学意义（P0.05）；模型组和工艺品2大剂量组小鼠悬尾不动时间时间分别为（98.29±36.90）s、（87.54±30.05）s，工艺品2大剂量组小鼠悬尾不动时间有缩短趋势，但差异无统计学意义。结论 精制工艺白金胶囊用于治疗慢性不可预知应激所致小鼠抑郁症的药效优于传统工艺。 　　关键词：白金胶囊；传统工艺；精制工艺；慢性不可预知应激；抑郁症；小鼠 　　DOI：10.3969/j.issn.1005-5304.2016.01.015 　　中图分类号：R285.5 文献标识码：A 文章编号：1005-5304（2016）01-0065-04 　　Effects of Different Processes of Baijin Capsule on Treatment of Mice with Chronic Unpredictable Stress-induced Depression NI Bo-ran， LIN Long-fei， ZHANG Hui， NI Jian （Beijing University of Chinese Medicine， Beijing 100029， China） 　　Abstract： Objective To evaluate the efficacy of different processes of Baijin Capsule to treatment of mice with chronic unpredictable stress-induced depression. Methods Chronic unpredictable stress was used to establish depression mice models. Experimental mice were divided into the following groups according to body mass： model group， positive medicine group， artware one （traditional process） high-dose and low-dose groups， and artware （refining process） two high-dose and low-dose groups. All medication groups were given relevant medicine for gavage. By detecting the two behavior indexes， immobility time of swimming and tail suspension of mice， the anti-depression effects of traditional process and refining process of Baijin Capsule were investigated. By detecting autonomic activities and body mass， tested medicine was examined for function state of central excitation and changing animal body. Results The times for automatic activities of Baijin Capsule in the model and artware （refining process） tw