不同抗凝剂自体血回输对输卵管妊娠破裂患者炎症因子影响.docVIP

不同抗凝剂自体血回输对输卵管妊娠破裂患者炎症因子的影响 　　摘 要：目的 探讨采用不同抗凝剂进行自体血回输的临床实用性和对输卵管妊娠破裂患者的炎症因子的影响。方法 选取我院2014年1月～2015年8月收治的输卵管妊娠破裂出血患者60例，随机分为H组和C组，每组30例。H组行肝素抗凝剂，C组行枸橼酸钠抗凝剂，收集术野失血进行自体血回输，检测回输后两组患者TNF-α、IL-6、IL-8、IL-10的变化。结果 两组患者TNF-α在T3和T6时与T1相比明显升高，IL-6、IL-8在T3、T4、T5是逐渐升高，T6时回落，IL-10在T2后持续升高直至T6，存在统计学意义（P0.01）。与H组比较，C组IL-6、IL-8和IL-10在T3、T4、T5、T6时浓度明显低于H组，存在统计学意义（P0.01）。结论 与肝素组比较，枸橼酸钠组自体血回输后体内炎症因子释放较少， 但操作繁琐、不安全，临床实用性低于肝素组。 　　关键词：枸橼酸钠；肝素；自体血回输；炎症因子； 　　中图分类号：R714.22 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.04.019 　　文章编号：1006-1959（2018）04-0059-03 　　Abstract：Objective To investigate the clinical practicability of autologous blood transfusion with different anticoagulants and its influence on inflammatory factors in patients with rupture of tubal pregnancy.Methods 60 patients with rupture of tubal pregnancy were selected from January 2014 to August 2015 in our hospital.They were randomly divided into group H and group C，with 30 cases in each group.Group H received heparin anticoagulant，group C received sodium citrate injection for transfusion，collecting blood loss from field operation and autotransfusion，and detected the changes of TNF-，IL-6，IL-8 and IL-10 in two groups after transfusion.Results The two groups of patients TNF- alpha at T3 and T6 compared with T1 increased significantly，IL-6，IL-8 in T3，T4，T5 increased gradually，T6 decreased，IL-10 increased continuously until after the increase，until there was statistical significanc（P0.01）.Compared with the H group，the concentrations of IL-6，IL-8 and IL-10 in group C were significantly lower than those of the H group at T3，T4，T5 and T6，and there was a statistical significance（P0.01）.Conclusion Compared with heparin group，the release of inflammatory factors in the sodium citrate group after autologous blood transfusion is less，but the operation is tedious and unsafe，and the clinical practicability is lower than that of heparin group. 　　Key words：Sodium citrate；Heparin；Autologous blood transfusion；Inflammatory factors 　　?卵管妊娠破裂是妇科常