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From by on October 11, 2010. For personal use only.
2010 116: 2215-2223
Prepublished online Jul 19, 2010;
doi:10.1182/blood-2009-10-163329
How I treat elderly patients with myeloma
Jayesh Mehta, Michele Cavo and Seema Singhal
Updated information and services can be found at:
/cgi/content/full/116/13/2215
Articles on similar topics may be found in the following Blood collections:
. How I Treat (50 articles)
. Free Research Articles (991 articles)
. Lymphoid Neoplasia (506 articles)
Information about reproducing this article in parts or in its entirety may be found online at:
/misc/rights.dtl#repub_requests
Information about ordering reprints may be found online at:
/misc/rights.dtl#reprints
Information about subscriptions and ASH membership may be found online at:
/subscriptions/index.dtl
Blood (print ISSN 0006-4971, online ISSN 1528-0020), is published
semimonthly by the American Society of Hematology, 1900 M St, NW, Suite
200, Washington
Copyright 2007 by The American Society of Hematology; all rights reserved.
From by on October 11, 2010. For personal use only.
How
I
treat
How I treat elderly patients with myeloma
Jayesh
Mehta,1
Michele
Cavo,2
and
Seema
Singhal1
1Robert
H.
Lurie
Comprehensive
Cancer
Center
of
Northwestern
University,
Chicago,
IL;
and
2Sera`gnoli
Institute
of
Hematology,
Bologna
University,
School
of
Medicine,
Bologna,
Italy
The
clinical
approach
to
older
patients
with
myeloma
has
to
be
modified
to
take
into
account
comorbidities
and
the
likelihood
of
higher
treatment-related
toxicity.
Individualization
of
management
and
adequate
supportive
therapy
are
important
to
obtain
the
best
response
while
minimizing
ad-
Introduction
verse
effects.
Corticosteroids,
novel
agents,
conventional
cytotoxic
agents,
and
high-dose
chemotherapy
with
auto-
transplantation
(modalities
used
in
younger
patients)
are
also
used
in
older
patients,
alt
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