功能性消化不良患者胃黏膜肥大细胞及5―羟色胺变化的研究.docVIP

功能性消化不良患者胃黏膜肥大细胞及5―羟色胺变化的研究 　　摘要：目的 初步探讨胃黏膜肥大细胞及5-羟色胺的变化在功能性消化不良患者发病机制中的作用。方法 选择符合功能性消化不良患者诊断标准的患者作为实验组，取健康志愿者作为对照组。应用免疫组化法检测胃黏膜肥大细胞含量。应用高效液相电化学检测法测定胃黏膜5-羟色胺浓度，结合临床资料数据对照比较。结果 ①从本研究中可以看出实验组和对照组在胃黏膜肥大细胞含量及胃黏膜5-羟色胺浓度都有显著性差异（P0.05）。②从本研究中可以看出实验组患者胃黏膜5-羟色胺浓度与胃黏膜肥大细胞数目、胃黏膜肥大细胞脱颗粒比率之间有明显相关性（P0.05）。结论 胃黏膜肥大细胞含量增高及胃黏膜5-羟色胺浓度的异常在功能性消化不良发病机制中起一定的作用。 　　关键词：功能性消化不良；肥大细胞；5-羟色胺 　　Clinical Study on the Changes of Gastric Mucosal Mast Cells and 5- in Patients with Functional Dyspepsia 　　LIU Tao，ZHANG Huan，CHEN Jie 　　（Affiliated Hospital of Jiangxi TCM University，Nanchang 330006，Jiangxi，China） 　　Abstract：Objective To investigate the effect of the changes of gastric mucosal mast cells and 5-HT in the pathogenesis of functional dyspepsia.Methods Patients with functional dyspepsia patients were selected as the experimental group， taking healthy volunteers as the control group. Detection of mast cell in gastric mucosa by immunohistochemical method. Application of high efficiency liquid phase electrochemical detection method for the determination of 5- concentration in gastric mucosa， and the comparison of clinical data.Results ① from the present study， we can see that there is a significant difference between the experimental group and the control group in the gastric mucosal mast cell content and gastric mucosal 5-HT serotonin concentration （P 0.05）.②from the present study， we can see that there is a significant correlation between the concentration of 5-HT in the gastric mucosa of the experimental group and the number of mast cells in gastric mucosa， and the percentage of mast cells in gastric mucosa （P0.05）.Conclusion Gastric mucosal mast cells increased and 5-HT concentration of gastric mucosa in the pathogenesis of functional dyspepsia. 　　Key words：Functional dyspepsia； Mast cell； 5-HT 　　功能性消化不良是临床上消化科门诊中最为常见的功能性疾病之一，占消化内科门诊大约为50%左右[1-2]。功能性消化不良病因复杂，对其发病机制目前尚未研究清楚，初步发现可能是多种因素及病因对功能性消化不良的发病起到了协同作用[3]，本研究是初步探讨胃黏膜肥大细胞及胃黏膜5-羟色胺含量在功能性消化不良患者发病机制中的作用。 　　1 资料与方法 　　1.1一般资料 收集在江西