人乳头瘤病毒感染与宫颈癌前病变和宫颈癌及其预后关系分析.docVIP

人乳头瘤病毒感染与宫颈癌前病变和宫颈癌及其预后的关系分析 　　【摘要】 目的：分析人乳?^瘤病毒感染与宫颈癌前病变、宫颈癌及其预后之间的关系。方法：抽取笔者所在医院2015年1月-2016年9月收治的宫颈癌前病变和宫颈癌患者各130例作为研究对象，分别对其HPV感染情况、造成感染的HPV分型分布情况进行比较。同时分析其治疗前后HPV感染率变化情况。结果：宫颈癌患者HPV感染率（90.8%）显著高于宫颈癌前病变（63.1%）；感染HPV的宫颈癌前病变和宫颈癌患者均以高危型HPV感染为主，同时宫颈癌患者高危HPV感染率（94.1%）显著高于宫颈癌前病变患者（61.0%）；不同分级宫颈癌前病变患者的高危HPV感染率比较，CINⅡ级和Ⅲ级患者显著高于Ⅰ级患者；而不同类型宫颈癌患者的高危HPV感染率比较，鳞癌患者感染率高于腺癌患者，高于其他类型患者，差异均有统计学意义（P0.05）。治疗后患者高危型HPV感染率均显著下降，与治疗前比较差异有统计学意义（P0.05）。结论：高危型人乳头瘤病毒感染是诱发宫颈癌前病变和宫颈癌的主要诱因，病情越严重，感染率越高，而通过早期筛查和积极治疗后，患者的HPV感染率显著降低，可对患者的预后改善情况进行预测。 　　【关键词】 人乳头瘤病毒感染； 宫颈癌前病变； 宫颈癌； 预后； 相关性 　　doi：10.14033/j.cnki.cfmr.2017.31.002 文献标识码 A 文章编号 1674-6805（2017）31-0003-03 　　【Abstract】 Objective：To analyze the relationship between human papillomavirus infection and cervical precancerous lesion，cervical cancer and its prognosis.Method：130 cases of cervical precancerous lesions and cervical cancer patients treated in the author’s hospital from January 2015 to September 2016 were selected as the subjects.The HPV infection and distribution of HPV were compared，the changes of HPV infection rate before and after treatment were analyzed.Result：The prevalence of HPV infection in cervical cancer patients（90.8%） was significantly higher than 63.1% in cervical precancerous lesions.HPV infection in cervical precancerous lesions and cervical cancer patients were mainly HR-HPV infection，and HR-HPV （94.1%） was significantly higher than 61.0% in patients with cervical precancerous lesions.The HR-HPV infection in patients with different grades of cervical precancerous lesions was significantly higher than that in patients with grade Ⅰ and grade Ⅲ.And in different types of cervical cancer patients with HR-HPV infection rate，there was a higher rate of infection in patients with squamous cell carcinoma than adenocarcinoma，higher than other types of patients， the differences were statistically significant（P0.05）.After treatment，the HR-HPV infection rate was significantly decreased，compared with before treatment were stati