双歧杆菌四联活菌胶囊治疗肠易激综合征的临床效果.docVIP

双歧杆菌四联活菌胶囊治疗肠易激综合征的临床效果 　　[摘要] 目的 观察双歧杆菌四联活菌胶囊治疗肠易激综合征（IBS）的临床效果。 方法 将2015年1～4月就诊于河北北方学院附属第二医院的60例确诊为肠易激综合征的患者依据随机数字法分为观察组和对照组，每组各30例；观察组给予双歧杆菌四联活菌胶囊治疗，对照组给予马来酸曲美布汀分散片治疗，疗程均为4周。观察两组患者服药后的临床疗效，统计治疗有效率。 结果 观察组患者21例患者治疗有效，对照组患者25例患者治疗有效，两组疗效比较差异有统计学意义（χ2=1.491，P 0.05）。 结论 双歧杆菌四联活菌胶囊与目前治疗IBS效果确切的马来酸曲美布汀分散片效果相当，可用于治疗IBS。 　　[关键词] 双歧杆菌四联活菌胶囊；马来酸曲美布汀分散片；肠易激综合征；益生菌 　　[中图分类号] R574 [文献标识码] A [文章编号] 1673-7210（2016）05（c）-0154-04 　　[Abstract] Objective To investigate the effect of Bifidobacterium Tetravaccine Capsules on irritable bowel syndrome （IBS）. Methods 60 patients with diarrhea-predominant irritable bowel syndrome in the Second Affiliated Hosipital to Hebei North University from January 2015 to April 2015 were divided into observation group and control group according to random number table method， with 30 patients in each group. Patients in observation group were given Bifidobacterium Tetravaccine Capsules， patients in control group were given Trimebutine Maleate Dispersible Tablets. The patients in each group were all treated with drug for four weeks. The effect was observed， and the effective rate was censused. Results There were 21 effectively treated patients in observation group， 25 effectively treated patients in control group， with statistical significance （χ2=1.491， P 0.05）. Conclusion The clinical efficacy of Bifidobacterium Tetravaccine Capsules and Trimebutine Maleate Dispersible Tablets are both good， and the clinical efficacy of Trimebutine Maleate Dispersible Tablets is sure. So Bifidobacterium Tetravaccine Capsules can be used in treating irritable bowel syndrome. 　　[Key words] Bifidobacterium Tetravaccine Capsules； Trimebutine Maleate Dispersible Tablets； Irritable bowel syndrome； Probiotics 　　肠易激综合征（irritable bowel syndrome，IBS）是临床上常见的一种胃肠道疾病，主要的临床表现为腹部不适感和腹痛，同时伴有排便习惯的改变，此症状通常反复发作或者持续存在，但缺乏可解释症状的形态学改变和生化异常，并且很难根治。在西方国家，具有IBS症状的人群占正常人群的10%～15%[1]。而在我国IBS的发病率通常会与患者的居住环境有关，一线大城市患病率通常高于三、四线小城市，广州大约为5.6%，北京大约为0.82%[2]。IBS患者与非IBS患者肠道菌群的数量具有较大不同，IBS患者肠