依达拉奉对心脏骤停患者血清TNF拨痢IL1βIL10及脑组织保护作用.docVIP

依达拉奉对心脏骤停患者血清TNF拨痢IL1β、IL10及脑组织的保护作用 　　【摘要】目的探讨依达拉奉对心脏骤停患者血清TNFα、IL1β、IL10及脑功能指标的影响。方法选择收治的68例心脏骤停经心肺复苏恢复自主循环患者，根据随机数字表法将患者分为两组，常规组34例患者在心肺复苏后未给予任何药物处理，依达拉奉组34例患者在心肺复苏后给予依达拉奉处理。观察两组患者复苏后即刻、复苏后3 h、复苏后12 h、复苏后24 h、复苏后48 h、复苏后72 h的TNFα、ILlβ、IL10水平，对比治疗后两组患者脑功能分级评价情况。结果两组患者复苏后即刻TNFα、ILlβ、IL10水平差异无统计学意义（P0.05），复苏后3 h、复苏后12 h、复苏后24 h、复苏后48 h、复苏后72 h两组的TNFα、ILlβ均显著升高（P0.01），IL10均显著降低。依达拉奉组患者复苏后3 h、复苏后12 h、复苏后24 h、复苏后48 h、复苏后72 h的TNFα、ILlβ水平显著低于常规组（P0.01），IL10水平显著高于常规组（P0.05或0.01）。依达拉奉组患者的脑功能分级评价显著优于常规组（P0.05）。结论依达拉奉能有效地降低心脏骤停经心肺复苏成功后患者的血清TNFα、ILlβ等促炎性细胞，而增加IL10等抑炎因子，减轻脑组织的损伤。 　　【关键词】依达拉奉；心脏骤停；细胞因子 　　中图分类号：R541文献标识码：ADOI：10.3969/j.issn2015.03.014 　　Protective effect of edaravone for serum levels of TNFalpha，IL1 beta， 　　IL10 and brain tissue of patients with cardiac arrest 　　LIN Jing，QIU Jianqing▲ 　　（Emergency Department，Affiliated Hospital of Binzhou Medical College，Dongying 256003，Shandong，China） 　　【Abstract】ObjectiveTo investigate effect of edaravone for serum levels of TNFα，IL1β，IL10 and brain function index of patients with cardiac arrest.Methods68 cases of cardiac arrest，who got spontaneous circulation after treating by cardiopulmonary resuscitation，were selected to this study.They were divided into conventional therapy group and edaravone group according to random number table，with 34 cases in each group.The conventional therapy group were not given any medication after cardiopulmonary resuscitation，while the edaravone group were given edaravone after cardiopulmonary resuscitation.Then，levels of TNFα，IL1β and IL10 at the moment of resuscitation，3 h after resuscitation，12 h after resuscitation，24 h after resuscitation，48 h after resuscitation，and 72 h after resuscitation were observed between groups.In addition，brain function classification evaluation after treatment in the two groups were compared.Results Difference of levels of TNFα，IL1β and IL10 at the moment of resuscitation of the two groups was not statistically significant（P0.05）.Levels of TNF