免疫功能与超敏C反应蛋白检验对小儿肺炎支原体肺炎临床意义.docVIP

免疫功能与超敏C反应蛋白检验对小儿肺炎支原体肺炎临床意义 　　【摘要】 目的 分析研究免疫功能与超敏C反应蛋白（hs-CRP）检验对小儿肺炎支原体肺炎（MPP）的临床价值。方法 125例MPP患儿， 将其按照患儿是否合并全身炎症反应综合征（SIRS）分为SIRS组（55例）和非SIRS组（70例）。并选取同期在本院参与体检的健康儿童50例作为对照组， 分别行免疫功能检查和hs-CRP检查， 比较各组受检儿童的检查结果。结果 MPP患儿与对照组健康儿童各项检测指标比较差异有统计学意义（P0.05）。SIRS组hs-CRP为（7.85±1.95）mg/L、免疫球蛋白（Ig）G为（14.26± 　　3.19）g/L、IgM为（1.95±0.52）g/L显著高于非SIRS组的（5.02±1.23）mg/L、（11.08±2.82）g/L、（1.77±0.47）g/L， 　　SIRS组的C3为（50.53±10.34）%、C4为（26.84±4.92）%、IgA为（1.10±0.21）g/L明显低于非SIRS组的（59.42±11.48）%、（32.14±5.87）%、（1.18±0.23）g/L， 差异均有统计学意义（P0.05）。结论 MPP患儿机体内同时存在体液免疫及细胞免疫异常的情况， 且其与患儿的病情进展息息相关， 而hs-CRP检测可对患儿的患病程度进行反映， 通过免疫功能与hs-CRP联合检验可以为患儿的诊断治疗提供指导依据。 　　【关键词】 小儿肺炎支原体肺炎；免疫功能；超敏C反应蛋白；诊断价值 　　DOI：10.14163/j.cnki.11-5547/r.2017.12.005 　　【Abstract】 Objective To analyze and research clinical value by immune function and high-sensitivity C-reactive protein （hs-CRP） test for pediatric mycoplasmal pneumoiae pneumonia （MPP）. Methods A total of 125 children patients with MPP were divided by their complicated systemic inflammatory response syndrome （SIRS） into SIRS group （55 cases） and non-SIRS group （70 cases）. There were 50 health children at the same time period as control group. They all received immune function and hs-CRP test to compare test outcomes. Results The difference of detection indexes between children patients with MPP and healthy children in the control group all had statistical significance （P0.05）. SIRS group had hs-CRP as （7.85±1.95） mg/L， immunoglobulin G （IgG） as （14.26±3.19） g/L， and IgM as （1.95±0.52） g/L， which were all obviously higher than （5.02±1.23） mg/L， 　　（11.08±2.82） g/L and （1.77±0.47） g/L in non-SIRS group. SIRS group had C3 as （50.53±10.34）%， C4 as （26.84±4.92）% and IgA as （1.10±0.21） g/L， which were much lower than （59.42±11.48）%， （32.14±5.87）% and （1.18±0.23） g/L in non-SIRS group. Their differences all had statistical significance （P0.05）. Conclusion There are humoral immunity and cellular immune abnormalities in children patients with MPP， and they are closely relat