凝血酶联合立止血用于小儿上消化道出血临床分析.docVIP

凝血酶联合立止血用于小儿上消化道出血临床分析 　　[摘 要] 目的：观察凝血酶联合立止血治疗小儿上消化道出血临床效果。方法：选取我院2013年11月到2014年11月收治的68例轻中度上消化道出血患儿，随机分为对照组与实验组，给予所有患儿补液、抑酸等基础治疗，对照组患儿口服凝血酶；实验组在对照组基础上加用立止血静注。结果：实验组止血时间（28.46±4.17）h，显著短于对照组的（48.16±5.64）h，差异具有统计学意义。实验组的治疗总有效率明显高于对照组，差异具有统计学意义（P0.05）。结论：凝血酶联合立止血治疗小儿的上消化道出血具有良好的疗效。 　　[关键词] 凝血酶；立止血；小儿；上消化道出血 　　中图分类号：R725.7 文献标识码：B 文章编号：2095-5200（2016）04-121-03 　　DOI：10.11876/mimt201604046 　　Clinical Analysis of the Efficacy of Thrombin and Reptilase In the Treatment of Pediatric Upper Gastrointestinal Hemorrhage WANG Ailan，WANG Anshui. （Department of paediatrics， Hanzhong peoples Hospital，Hanzhong 723000，China） 　　[Abstract] Objective： To observe the clinical efficacy of thrombin and reptilase in the treatment of pediatric upper gastrointestinal hemorrhage. Methods： Selected 68 cases of children with mild or moderate upper gastrointestinal hemorrhage admitted from November 2013 to November 2014 and randomly divided them into the control group and experimental group， providing them all with basic treatments like fluid infusion and acid suppression. Both groups take oral thrombin while those of the experimental group receive intravenous injection of reptilase in addition. Results：The average hemostasis time of the control group（28.46±4.17）h is obviously shorter than that of the other group（48.16±5.64）h and the difference has statistical significance.The total effective rate of the control group is obviously higher than that of the other group and the difference has statistical significance（P0.05）. Conclusion： A combined application of thrombin and reptilase shows a good clinical efficacy in the treatment of pediatric upper gastrointestinal hemorrhage. 　　[Key words] thrombin；reptilase；pediatric；upper gastrointestinal hemorrhage 　　上消化道出血（UGB）是屈氏韧带以上消化道发生出血[1]。临床表现因病因、出血速度的不同而不同，小儿上消化道出血是临床常见急症，小儿循环血量低于成人，出血危险性高于成人[2]。凝血酶为牛或猪血中提取的凝血酶无菌冻干品，能促使纤维蛋白原转化为纤维蛋白而使血液凝固[3]。立止血是一种酶性止血剂，具有类凝血酶的效力和活性，能促进出血部位的血小板聚集，释放凝血因子，是一种较为理想的止血剂[4]。文献报道[5]，以上两种药物联合使用能够充分止血。本研究观察两药联用治疗小儿上消化道出