冠心病发病机制及与内皮素一氧化氮相关性研究进展.docVIP

冠心病发病机制及与内皮素一氧化氮相关性研究进展 　　[摘要] 本文从冠心病的危险因素和发病机制入手，阐述了内皮素（ET）和一氧化氮（NO）是血管内皮细胞分泌的重要血管活性物质，对维持血管正常的舒缩有重要的意义；若内皮细胞受损，则可引起ET和NO分泌失衡，导致血管舒缩异常，最终可导致冠心病的发生和发展。 　　[关键词] 冠心病；血管内皮功能；ET；NO 　　[中图分类号] R541.61 [文献标识码] A [文章编号] 1673-7210（2014）04（b）-0167-03 　　[Abstract] This paper starts from the risk factors and pathogenesis of coronary heart disease， expounds that ET and NO are important vasoactive substances secreted by vascular endothelial cells， which have important meaning to maintain normal vascular vasomotion； if the endothelial cells are damaged， which can cause secretion of ET and NO out of bala