加味阳和汤治疗膝骨性关节炎长期疗效分析.docVIP

加味阳和汤治疗膝骨性关节炎长期疗效分析 　　[摘要] 目的 探讨加味阳和汤治疗膝骨性关节炎的长期疗效。 方法 选取本院2014年12月～2015年12月收治的144例膝骨性关节炎患者作为研究对象，随机分成观察组和对照组，各72例。对照组给予常规临床治疗，观察组在对照组的基础上给予加味阳和汤治疗。比较两组治疗前后的血清基质金属蛋白酶-3（MMP-3）、MMP-9水平以及治疗12个月后的疗效，评价两组的安全性。 结果 两组治疗后的MMP-3、MMP-9水平显著低于治疗前，差异有统计学意义（P0.05）。观察组治疗后的MMP-3、MMP-9水平显著低于对照组治疗后，差异有统计学意义（P0.05）。观察组的优良率为91.67%，显著高于对照组的79.17%，差异有统计学意义（P0.05）。两组的安全性均为Ⅰ级。 结论 在常规治疗的基础上联合应用加味阳和汤治疗膝骨性关节炎可以显著提高患者的长期疗效，且具有安全性。 　　[关键词] 膝骨性关节炎；加味阳和汤；中医辨证；长期疗效 　　[中图分类号] R684.3 [文献标识码] A [文章编号] 1674-4721（2016）05（c）-0100-03 　　Long term effect analysis of modified Yanghe decoction in the treatment of knee osteoarthritis 　　WU Zhi-hui CHEN Shi 　　Yuedong Hospital，the Third Hospital Affiliated to Sun Yat-Sen University，Meizhou 514000，China 　　[Abstract] Objective To explore the long term effect of modified Yanghe decoction in the treatment of knee osteoarthritis. Methods 144 knee osteoarthritis patients from December 2014 to December 2015 in our hospital were selected and randomly divided into the observation group and the control group，72 cases in each group.The control group was given routine clinical treatment，the observation group was given modified Yanghe decoction on the basis of the control group.The level of serum matrix metalloproteinase-3 （MMP-3） and matrix metalloproteinase-9 （MMP-9） before and after treatment，the effect after treatment for 12 months in the two groups was compared，the safety in the two groups was evaluated. Results The level of MMP-3 and MMP-9 after treatment in the two groups was lower than that before treatment，with significant difference （P0.05）.The level of MMP-3 and MMP-9 after treatment in the observation group was lower than that in the control group after treatment，with significant difference （P0.05）.Excellent and good rate in the observation group was 91.67%，which was higher than 79.17% in the control group，with significant difference （P0.05）.Both of the safety in the two groups was grade Ⅰ. Conclusion Further given modified Yanghe decoction on the basis