加味四妙汤对急性痛风性关节炎患者血清白介素―68和基质金属蛋白酶―3水平影响及疗效观察.docVIP

加味四妙汤对急性痛风性关节炎患者血清白介素―68和基质金属蛋白酶―3水平影响及疗效观察 　　[摘要] 目的 探讨加味四妙汤对急性痛风性关节炎患者血清白介素-6（IL-6）、白介素-8（IL-8）和基质金属蛋白酶-3（MMP-3）水平的影响及疗效观察。 方法 将2010年1月～2013年7月浙江省嘉兴市中医院骨伤科门诊84例急性痛风性关节炎患者随机分为观察组和对照组，每组42例。两组患者均予以饮食控制和多饮水等常规处理，并加用秋水仙碱口服，首剂1 mg，之后0.5 mg/次，每2小时1次，24 h后改0.5 mg，3次/d。观察组在此基础上患者加用加味四妙汤，每日1剂，水煎服，连用14 d。比较两组患者治疗前后血清IL-6、IL-8和MMP-3水平的变化，并进行疗效观察。 结果 治疗14 d后，两组患者血清IL-6、IL-8和MMP-3水平[（48.26±10.76）ng/L、（1.32±0.32）μg/L和（81.55±20.52）ng/mL；（34.37±8.13）ng/L、（0.89±0.25）μg/L和（64.28±13.19）ng/mL]均较治疗前明显下降[（70.19±16.12）ng/L、（1.73±0.43）μg/L和（103.92±27.16）ng/mL；（69.52±14.02）ng/L、（1.68±0.34）μg/L和（99.74±26.19）ng/mL]（t = 2.45、2.27、2.19、3.25、3.09、2.91，P 0.01或P 0.05），且观察组下降值比对照组更明显（t =2.34、2.43、2.29，P 0.05）；且观察组总有效率明显高于对照组（92.86%比76.19%）（χ2=4.46，P 0.05）。 结论 加味四妙汤治疗急性痛风性关节炎具有较好效果，能明显改善患者的症状及体征，有助于关节功能的恢复，作用与其降低血清IL-6、IL-8和MMP-3水平以及抑制局部炎症反应过程密切有关。 　　[关键词] 急性痛风性关节炎；加味四妙汤；白介素-6；白介素-8；基质金属蛋白酶-3 　　[中图分类号] R259.897[文献标识码] A[文章编号] 1673-7210（2014）06（c）-0114-03 　　Influence and curative effect observation of Jiawei Simiao Decoction on serum interleukin-6 and 8 and matrix metalloprotease-3 levels of patients with acute gouty arthritis 　　JU Jianwei 　　Department of Orthopedics and Traumatology， Traditional Chinese Medicine Hospital of Jiaxing City， Zhejiang Province， Jiaxing 314001， China 　　[Abstract] Objective To discuss influence and curative effect observation of Jiawei Simiao Decoction on serum interleukin-6 （IL-6） and interleukin-8 （IL-8） and matrix metalloprotease-3 （MMP-3） levels of patients with acute gouty arthritis. Methods 84 cases of patients with acute gouty arthritis， who were in Department of Orthopedics and Traumatology of Traditional Chinese Medicine Hospital of Jiaxing City from January 2010 to July 2013 were divided into observation group and control group at random， with 42 cases respectively. The patients in two groups were given routine treatment like diet control， drinking plenty of water and etc， and were additionally given colchicin through the mouth， with the first dose