利奈唑胺治疗神经外科手术致颅内感染临床效果分析.docVIP

利奈唑胺治疗神经外科手术致颅内感染临床效果分析 　　[摘要] 目的 探讨利奈唑胺治疗神经外科手术致颅内感染的临床效果。方法 方便选取福建省省立医院2014年2月―2016年2月收治的80例神经外科手术致颅内感染患者作为研究对象，在确定所有患者或家属均已经如实掌握此次研究方案具体内容并签署知情同意书后随机分为对照组及研究组各40例，对照组采取万古霉素治疗，研究组采取利奈唑胺治疗，比较两组患者临床疗效。结果 研究组经利奈唑胺治疗，总有效率90%，与对照组77.5%相比较，差异具有统计学意义（P0.05）；两组患者脑脊液指标比较，差异具有统计学意义（P0.05）。结论 利奈唑胺治疗神经外科手术致颅内感染疗效相较于万古霉素更佳，值得在今后临床治疗工作中推广使用。 　　[关键词] 利奈唑胺；万古霉素；神经外科；颅内感染 　　[中图分类号] R619.3 [文献标识码] A [文章编号] 1674-0742（2016）07（c）-0143-03 　　[Abstract] Objective To observe the effect of linezolid in the treatment of Department of Neurosurgery surgery clinical effect of intracranial infection. Methods Convenient selection a total of Fujian Provincial Hospital from February 2014 to February 2016 80 patients with neurosurgical operation caused by intracranial infection patients as the research object， in identifying all patients or their families have been accurately grasp the specific content of the research program and signed the informed consent book were randomly divided into control group and study group， 40 cases in each， the control group was treated with vancomycin in the treatment， the research group taking linezolid therapy， compared two groups of patients with clinical curative effect. Results Study group after treatment with linezolid， the total efficiency of 90%， compared with the control group of 77.5%， the difference is statistically significant （P 0.05）； two groups of patients with cerebrospinal fluid index comparisons， the difference is statistically significant （P 0.05）. Conclusion Linezolid in the treatment of Neurosurgery induced intracranial infection efficacy compared to vancomycin is better， so it is worth to be popularized in clinical treatment in the future. 　　[Key words] Linezolid； Vancomycin； Department of Neurosurgery； Intracranial infection 　　手术后颅内感染（intracranial infeion）是神经外科手术严重的并发症之一，不但影响手术效果，延长康复时间，增加住院费用，而且严重者危及患者生命安全[1]。因此，正确选择抗菌素，及时、有效地控制颅内感染是改善预后的关键所在。该研究对福建省省立医院2014年2月―2016年2月40例神经外科手术致颅内感染患者实施利奈唑胺治疗，取得了理想的临床疗效，现报道如下。 　　1 资料与方法 　　1.1 一般资料