双黄连注射液对肺炎小儿血清CRP降钙素原及IL―6水平影响.docVIP

双黄连注射液对肺炎小儿血清CRP降钙素原及IL―6水平影响 　　[摘要] 目的 探讨双黄连注射液对肺炎小儿血清CRP、降钙素原及IL-6水平的影响，为临床治疗提供参考意见。方法选取该院2013年1月―2016年1月所收治肺炎患儿94例，随机分为研究组和对照组。对照组47例，在常规对症治疗基础上，采用头孢噻肟钠进行抗感染治疗；研究组47例，加用双黄连注射液。记录两组患者治疗前后血清CRP、降钙素原及IL-6水平。 结果 两组患儿经治疗后，血清CRP、PCT及IL-6均有显著下降，与治疗前相比较，差异具有统计学意义（P0.05）；治疗后，研究组血清CRP为（5.18±0.69）、PCT为（0.15±0.03）、IL-6为（10.55±1.23），显著低于对照组的（8.14±0.79）、（0.51±0.07）、（17.22±2.11），差异具有统计学意义（P0.05）。 结论 双黄连注射剂应用于小儿肺炎临床治疗中具有肯定疗效，其疗效机制与降低血清CRP、PCT及IL-6水平密切相关，值得临床加深研究和推广应用。 　　[关键词] 降钙素原；C-反应蛋白；IL-6；小儿肺炎 　　[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2016）06（c）-0142-03 　　[Abstract] Objective To investigate the effect of Shuanghuanglian Injection on infantile pneumonia serum CRP， procalcitonin and IL-6 levels， and provide reference for clinical treatment. Methods 94 cases of pneumonia in our hospital from January 2013 to January 2016 were randomly divided into study group and control group， cases were randomly divided into study group and control group. In the control group， 47 cases were treated with anti infective therapy based on conventional symptomatic treatment， 47 cases in the study group were treated with the injection of Shuang Huang Lian injection. The serum levels of CRP， and IL-6 were recorded before and after treatment in two groups of patients. Results Two groups of patients after treatment， serum CRP， PCT and IL-6 were significantly decreased， compared with that before treatment， the difference is statistically significant （P 0.05）； after treatment， the serum CRP to （5.18±0.69）， PCT is （0.15±0.03） and IL-6 （10.55± 1.23） was significantly lower than that in control group （8.14±0.79）， （0.51±0.07）， （17.22±2.11）， and the difference is statistically significant （P 0.05）. Conclusion Application of Shuang Huang Lian injection in clinical treatment of children with pneumonia has definite curative effect， its curative effect mechanism and reduce the level of serum CRP， PCT and IL-6 are closely related， it is worthy of clinical research and popularization and application. 　　[Key w