右美托咪定在成人鼾症手术苏醒期应用研究.docVIP

右美托咪定在成人鼾症手术苏醒期应用研究 　　[摘要] 目的 ?^察右美托咪定对成人鼾症手术苏醒期不良事件的影响。 方法 收集2014年6月～2016年5月淮安市第一人民医院分院ASAⅠ～Ⅱ级全麻下施行鼾症手术患者70例，随机分为观察组和对照组，每组35例。观察组于手术结束前30 min静脉泵注右美托咪定0.5 μg/kg，输注时间为15 min；对照组输注等量的生理盐水。记录两组患者手术结束前30 min（T0）、手术结束时（T1）、气管拔管时（T2）和气管拔管后5 min（T3）、气管拔管后15 min（T4）、气管拔管后30 min（T5）的平均动脉压（MAP）和心率（HR）；观察两组患者麻醉苏醒期恢复情况及术后24 h不良反应的发生情况。 结果 观察组T1～T4时点MAP、HR较T0时无明显变化（P 0.05）；对照组T1～T4时点的MAP、HR较T0时明显增高（P 0.05）。 结论 右美托咪定能明显减轻成人鼾症手术患者全麻苏醒期气管拔管的心血管反应，且无明显不良反应。 　　[关键词] 右美托咪定；鼾症；气管拔管反应 　　[中图分类号] R614.2 [文献标识码] A [文章编号] 1673-7210（2017）03（a）-0061-04 　　The application of Dexmedetomidine in the recovery period of surgery for adult with sleep apnea 　　ZHOU Honggang XU Hongmei 　　Department of Anesthesiology， Branch Hospital of Huaian First Peoples Hospital， Jiangsu Province， Huaian 223002， China 　　[Abstract] Objective To observe the effect of Dexmedetomidine on adverse events in the recovery period of surgery for adult with sleep apnea. Methods From June 2014 to May 2016， 70 patients who recieved surgery for sleep apnea with general anesthesia of ASA Ⅰ-Ⅱ grade in Branch Hospital of Huaian First Peoples Hospital were randomly divided into the observation group and the control group， each group had 35 cases. 30 min before the end of the operation， the observation group patients were given Dexmedetomidine 0.5 μg/kg by intravenous pumping， and the infusion time was 15 min. In the control group， the same amount of saline was infused by the same way. Mean arterial pressure （MAP） and heart rate （HR） were recorded at the following time points： 30 min before the end of the surgery （T0）， the end of the operation （T1）， tracheal extubation （T2）， 5 min after tracheal extubation （T3）， 15 min after tracheal extubation （T4）， and 30 min after tracheal extubation （T5）. The recovery of anesthesia and the incidence of adverse reactions at 24 h after operation were observed. Results Compared with those at T0， there were no significant differences in MAP and HR at T1-T4 in the observation group （P 0.05）.