双相情感障碍与单相抑郁症患者之间促炎细胞因子水平比较分析.docVIP

双相情感障碍与单相抑郁症患者之间促炎细胞因子水平比较分析 　　【摘要】 目的：研究?p相情感障碍（BD）、单相抑郁（UD）、健康人群中促炎细胞因子可溶性白细胞介素-6受体（sIL-6R），1型可溶性肿瘤坏死因子受体（sTNF-R1）和单核细胞趋化蛋白-1（MCP-1）水平差异，探讨BD、UD的炎症机制。方法：以初治BD患者30例、UD患者35例和正常对照（NC）30例为研究对象，ELISA检测三组人群外周静脉血中的sIL-6R、sTNF-R1、MCP-1浓度，去除MADRS评分、YMRS评分、吸烟、合并症和BMI混杂因素影响，多元回归分析BD、UD患者中三种炎症因子的水平差异。结果：BD组合并症比例、吸烟比例、BMI均高于UD组（P=0.033、0.012、0.040）。BD组外周血中sIL-6R，sTNF-R1，MCP-1浓度均高于UD组（P=0.021、0.023、0.035）。有合并症患者与无合并症者比较，具有更高的sIL-6R、sTNF-R1和MCP-1水平（P=0.002、0.001、0.001）。BMI≥25 kg/m2患者的sIL-6R、sTNF-R1和MCP-1水平较BMI25 kg/m2高（P=0.031、0.026、0.030）。去除混杂因素，多元回归分析结果表明sIL-6R、sTNF-R1、MCP-1水平在BD组和UD组比较差异有统计学意义（P=0.002，0.006，0.012）。结论：BD组sIL-6R、sTNF-R1和MCP-1水平较UD组高，这表明BD中可能存在更严重的炎症失调。 　　【关键词】 双相情感障碍； 单相抑郁症； 促炎细胞因子 　　【Abstract】 Objective：To investigate the level differences of pro-inflammatory cytokines including soluble interleukin-6 receptor（SIL-6R），soluble tumor necrosis factor receptor type 1 （sTNF-R1）， monocytechemotactic protein-1（MCP-1）among bipolar disorder （BD），unipolar depression （UD） and normal controls （NC）groups，to explore the inflammatory mechanism in BD and UD.Method：Study subjects were BD of 30 cases，UD of 35 cases and normal controls（NC）of 30 cases.Pro-inflammatory cytokines， including sIL-6R，sTNF-R1），MCP-1 were assessed in all subjects by enzyme-linkedimmunosorbent assays（ELISA）.The multiplevariant regression model was used to comparepro-inflammatory cytokines between BD and UD，while controlling for the confounding factors including MADRS scores，YMRS scores，smoking，medical comorbidity，and body mass index（BMI）.Result：The BD group had significantly higher smoking rate，more medical comorbidity，higher BMI than the UD group（P=0.033，0.012，0.040）.The levels of sIL-6R，sTNF-R1，and MCP-1 in BD group were significantly higher than the UD group（P=0.021，0.023，0.035）.Patients with comorbidities had higher levels of sIL-6R， sTNF-R1 and MCP-1（P=0.002，0.001，0.001）.The levels of sIL-6R，sTNF-R1 and MCP-1 in BMI≥25 kg/m2 group were higher than BMI 25 kg/m2 group（P=0.031，0.026，0.030）.Controlli