台州市艾滋病患者服药依从性及影响因素临床研究.docVIP

台州市艾滋病患者服药依从性及影响因素临床研究 　　【摘要】目的：探讨艾滋病患者服药依从性的影响因素，对患者进行干预提高患者用药依从性。方法：选取艾滋病患者577例，根据其用药依从情况分为两组。对两组患者社会人口学因素、药物因素以及治疗因素进行调查并进行统计和比较。结果：依从良好组患者年龄、病程、用药种类以及药物应用时间均明显低于依从差组，年收入明显高于依从差组。两组比较差异有统计学意义（P0.05）。依从良好组患者中女性、高中及以下文化程度、已婚者、对疾病知识和药物知识了解、心理健康者、医疗服务及医患关系良好、家属配合良好以及非自费者均明显多于依从差者；酗酒、药物滥用以及有药物不良反应者均明显少于服药依从性差者。上述比较两组差异有统计学意义（P0.05）。经Logistic回归多因素分析，患者的年龄、年收入、药物应用种类和时间、对疾病和药物知识掌握情况、是否存在不良反应、家属配合程度以及医疗费用支付方式是影响艾滋病患者服药依从性的独立危险因素（P0.05）。结论：艾滋病患者大多服药依从性良好，而影响其用药依从性的因素多样，包括患者自身因素，也包括药物因素和治疗因素，在临床工作中可以通过对影响因素进行干预而提高患者的服药依从性。 　　【关键词】艾滋病；服药依从性；影响因素 　　【Abstract】Objectives： To investigate the AIDS medication compliance factors， intervention patients improve patient medication compliance. Methods： 577 cases of AIDS， according to their medication adherence were divided into two groups. For sociodemographic factors， drug factors， and treatment factors were investigated and the two groups were statistically and compared. Results： The age of good compliance group， duration， types of medication and drug use were significantly lower than the compliance time difference between groups was significantly higher than the annual income of poor adherence group. The difference was statistically significant （P0.05）. Good compliance female patient group， high school education or less， married， disease knowledge and knowledge about drugs， mental health person， medical services and doctor-patient relationships， families with good and caught his own expense significantly more than non-poor compliance persons； alcoholism， drug abuse， and there is significantly less adverse drug reactions caught with poor medication compliance. The comparison between the two groups was statistically significant （P0.05）. Logistic regression multivariate analysis， age， annual income， type and timing of drug use， disease and drug knowledge to grasp the situation， the existence of adverse reactions， as well as with the families of the extent of the impact of payment of medical expenses AIDS medication compliance inde