四联疗法联合口腔洁治对胃溃疡患者胃幽门螺杆菌根除临床疗效观察.docVIP

四联疗法联合口腔洁治对胃溃疡患者胃幽门螺杆菌根除临床疗效观察 　　【摘要】 目的 探究四?疗法联合口腔洁治对胃溃疡患者胃幽门螺杆菌（Hp）根除的临床治疗效果， 为临床医学提供治疗经验。方法 120例经14碳呼气试验（14C-UBT）确诊胃Hp感染阳性且Hp唾液测试板（HpS）确诊口腔Hp感染阳性的胃溃疡患者， 以随机分组方式分为观察组和对照组， 每组60例。观察组患者给予10 d四联疗法和口腔清洁疗法进行干预， 对照组患者仅给予10 d四联疗法， 并不进行口腔清洁护理。比较两组治疗结束后1个月的胃Hp根除、口腔Hp阳性情况， 以及治疗结束后3个月的胃Hp复发、口腔Hp阳性情况。结果 治疗结束后1个月， 观察组患者胃Hp根除率及口腔Hp阳性率分别为90.0%、21.7%， 均明显优于对照组的70.0%、65.0%， 差异具有统计学意义（P0.05）。治疗结束后3个月， 观察组患者胃Hp复发率及口腔Hp阳性率分别为13.3%、20.0%， 均明显低于对照组的41.7%、61.7%， 差异具有统计学意义（P0.05）。结论 采用四联疗法联合口腔洁治对胃溃疡患者进行干预， 能够有效保证患者的胃Hp指数维持正常， 使患者口腔Hp指数维持正常。口腔Hp可能是导致胃溃疡疾病复发的原因。 　　【关键词】 四联疗法；口腔洁治；胃溃疡；幽门螺杆菌；根除 　　DOI：10.14163/j.cnki.11-5547/r.2018.09.058 　　【Abstract】 Objective To investigate the clinical treatment effect of quadruple therapy combined with oral scaling on eradication of gastric helicobacter pylori （Hp） in gastric ulcer patients， so as to provide treatment experience for clinical medicine. Methods A total of 120 gastric ulcer patients with positive gastric Hp infection confirmed by 14C-urea breath test （14C-UBT） and positive oral Hp infection confirmed by Hp saliva test plate （HPS） were randomly divided into observation group and control group， with 60 cases in each group. The observation group received 10 d of quadruple therapy combined with oral scaling for intervention， and the control group received 10 d of quadruple therapy without oral cleaning nursing. Comparison were made on gastric Hp eradication and oral Hp positive status after 1 month of treatment， and gastric Hp recurrence and Hp positive status after 3 months of treatment between the two groups. Results 1 month after the end of the treatment， the observation group had eradication rate of gastric Hp and positive rate of Hp in oral cancer respectively as 90.0% and 21.7%， which were 13.3% and 20.0% at 3 months after the end of the treatment. 　　1 month after the end of the treatment， the control group had eradication rate of gastric Hp and positive rate of Hp in oral cancer respectively as 70.0% and 65.0%， which were 41.7% and