基于关联规则挖掘痛风性关节炎中医内外合治对患者免疫炎症等指标影响.docVIP

基于关联规则挖掘痛风性关节炎中医内外合治对患者免疫炎症等指标影响 　　【摘 要】目的：??用关联规则和统计学方法分析刘健采用中医健脾单元疗法治疗痛风性关节炎对患者免疫、炎症及氧化指标的影响，为优化治疗提供依据。方法：搜集并整理安徽中医药大学第一附属医院电子病例系统所录入的痛风性关节炎患者的资料。采用SPSS 17.0、SPSS Clementine 12.0软件和Aprior模块分析中药、外用药与实验室指标变化的关系。结果：①治疗后，单纯内治组患者的免疫指标补体C3，炎症指标红细胞沉降率（ESR）、超敏C-反应蛋白（hs-CRP）、α1-酸性糖蛋白（α1-AGP），尿酸（UA）均有所降低（P 0.05）；内外合治组患者红细胞计数、血红蛋白浓度、血小板计数均有所上升（P 0.05或P 0.01）；免疫指标C3、C4，炎症指标ESR、hs-CRP、α1-AGP，UA均有所降低（P 0.05或P 0.01）；内外合治组患者ESR、hs-CRP、α1-AGP较单纯内治组患者改善更为明显（P 0.05或P 0.01）；②所用中药多集中在健脾利湿、清热解毒、活血化瘀、祛风除湿4类，提取每类使用频次前5位的中药共20味；③在关联规则置信度设为70%，支持度设为20%条件下提取值与指标关联较高的前2味中药，即茯苓、薏苡仁、白术、猪苓、车前草、蒲公英、山慈菇、大黄、丹参、桃仁、红花、威灵仙12味中药。结论：刘健在治疗痛风性关节炎时所采取的健脾单元综合疗法配伍明确，组方精炼，疗效确切。 　　【关键词】 痛风性关节炎；关联规则；中药；健脾单元疗法 　　On the Influence of Internal and External Treatment of Gouty Arthritis with Chinese Medicine on Patients’ Immune and Inflammatory Indexes based on Association Rules 　　SONG Qian，LIU Jian，XIN Ling，ZHOU Qiao，HUANG Dan，GUO Jin-chen 　　【ABSTRACT】Objective：To analyze the influence of Liu Jians method of treating gouty arthritis with Unit Therapy of Invigorating Spleen on patients’ immune，inflammatory and oxidative indexes using association rules and statistical methods in order to optimize treatment.Methods：Data of patients with gouty arthritis were collected from the First Affiliated Hospital of Anhui University of Chinese Medicine and sorted.Softwares SPSS 17.0 　　and SPSS Clementine 12.0 and Aprior module were used to analyze the relationship between Chinese medicine，externally applied medicine and laboratory indexes.Results：①After treatment，C3，ESR，hs-CRP，α1-AGP 　　and UA of patients with internal treatment decreased（P 0.05）.Red blood cell count，hemoglobin concentration and platelet count in patients with combined internal and external treatment increased（P 0.05 or P 0.01）. 　　Immune indexes C3，C4 and inflammatory indexes ESR，hs-CRP，α1-AGP and UA decreased（P 0.05 　　or P 0.01）.ESR，hs-CRP and α1-AGP in patients with combined treatment were improved compared with those with only internal tre