复方甘草酸苷联合窄谱UVB治疗玫瑰糠疹疗效观察.docVIP

复方甘草酸苷联合窄谱UVB治疗玫瑰糠疹疗效观察 　　【摘要】 目的 观察复方甘草酸苷联合窄谱UVB治疗玫瑰糠疹的临床疗效。方法 72例患者随机分为治疗组(37例,口服复方甘草酸苷联合窄谱UVB照射治疗)和对照组(35例,仅用窄谱UVB照射治疗),观察疗效。结果 1个疗程后,治疗组总有效率为75.7%,对照组为48.6%,差异显著(χ?2=5.64,P0.05);2个疗程后,治疗组总有效率为89.2%,对照组为68.6%,差异显著(χ?2=4.64,P0.05)。治疗过程中观察到治疗组患者红斑鳞屑减少、消退时间及瘙痒减轻、消失时间均明显少于对照组,差异显著(P0.05)。结论 复方甘草酸苷联合窄谱UVB治疗玫瑰糠疹安全有效。 　　【关键词】 玫瑰糠疹;复方甘草酸苷;窄谱UVB 　　 　　Compound Glycyrrhizin and Narrow-band ultraviolet B in treatment of pityriasis rosea 　　YAN Xun,MA Xue-liang.Department of Dermatology, Tengzhou Central People’s Hospital,Shandong Tengzhou 277500,China 　　 　　【Abstract】 Objective To observe the clinical efficacy of compound glycyrrhizin and narrow-band ultraviolet B in treatment of pityriasis rosea.Methods 72 patients were randomly divided into two groups. The patients of treatment group (37, co-compound glycyrrhizin combined with narrow-band ultraviolet B) and the patients of control group (35, only narrow-band ultraviolet B), Observation of effective.Results After one course of treatment, the efficacy rate of patients in treatment group was 75.7%, 57.1% in the control group, there was a statistically significant difference between the two groups (χ?2=5.64, P0.05). After two courses of treatment, the efficacy rate of patients in treatment groups was 89.2%, 80.0% in the control group, there was a statistically significant difference between the two groups (χ?2=4.64, P0.05). The regression time of erythema, squamae and pruritus in the treatment group were significantly shorter than that of the control group (P0.05). Conclusion Co-compound glycyrrhizin combined with Narrow - band ultraviolet B is a preferable therapy for treatment of pityriasis rosea. 　　【Key words】 Pityriasis rosea;Compound glycyrrhizin;Narrow-band ultraviolet B 　　 　　? 　　作者单位:277500滕州市中心人民医院皮肤科 　　 　　玫瑰糠疹是一种较为常见的自限性炎症性皮肤病,病程较长,目前尚缺乏特效药物。笔者自2008年6月至2009年6月采用复方甘草??苷联合窄谱UVB(NB-UVB)照射治疗玫瑰糠疹72例,取得满意疗效,现报告如下。 　　1 资料和方法 　　1.1 临床资料 72例患者均来自于2008年6月至2009年12月我科门诊, 临床表现为躯干及四肢近端见大小不等的圆形或椭圆形的玫瑰色斑疹,表面有少许细碎糠状鳞屑,其长