多囊卵巢综合症不孕患者改良超长方案HCG日LH水平与IVFICSI―ET结局关系.docVIP

多囊卵巢综合症不孕患者改良超长方案HCG日LH水平与IVFICSI―ET结局关系 　　[摘要] 目的 探讨改良超长降调节方案绒毛膜性腺激素（HCG）日血清黄体生成素（LH）水平与多囊卵巢综合症（PCOS）不孕患者体外受精/卵胞浆内单精子显微注射-胚胎移植技术（IVF/ICSI-ET）结果的关系。方法 方便选取2013年6月―2016年2月在郑州大学附属洛阳中心医院采用改良超长方案的PCOS患者200例，所有患者促排卵启动日LH0.5 mIU/mL。按照扳机日LH水平分为A、B两组。A组150例，LH0.5 mIU/mL；B组50例， LH≤0.5 mIU/mL。比较各组取卵数、优胚率、胚胎种植率、临床妊娠率、流产率。结果 取卵数各组间差异无统计学意义（P0.05）；A组与B组比较，优胚率（69.4% VS 60.7%）、胚胎种植率（40.8% VS 36.9%）、临床妊娠率（62.0% VS 46.0%），差异均有统计学意义（P0.05）；流产率A组为4.3%，低于B组的17.4%，差异有统计学意义（P0.05）。结论 改良超长方案PCOS患者HCG日适当的LH水平有助于改善临床结局，LH0.5mIU/ml可取消胚胎移植。 　　[关键词] 多囊卵巢综合征；改良超长降调方案；LH；IVF/ICSI-ET 　　[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2016）08（c）-0090-04 　　The Study of Serum LH Level on the Day of HCG and the Outcome for IVF/ICSI-ET of Modified Super-Long Protocol in Patients with PCOS 　　ZHOU Xiao-jing 　　Reproductive Center of Luoyang Central Hospital Affiliated Zhengzhou University， Luoyang，Henan Province，471000 China 　　[Abstract] Objective To explore the serum LH level on the day of HCG and the outcome for in vitro fertilization/intracytoplasmic sperm injection-embro transfer（IVF/ICSI-ET） of modified super-long protocol in patients with polycystic ovarian syndrom（PCOS）. Methods Convenient selection a total of 200 IVF/ICSI-ET cycles with PCOS had undergone modified super-long protocol during June 2013 to February 2016 in Luoyang Central Hospital Affiliated Zhengzhou University. According to the level of serum LH of the day of HCG， all cases were divided into two groups： A group including 150 cases with the level of LH over than 0.5 mIU/mL，B group including 50 cases with the level of LH less than 0.5 mIU/mL. Several key parameters of the two groups ，including retrieved oocyte number， high qualified embryo rate， embryo implantation rate ， clinical pregnant rate and abortion rate， were compared and analyzed. Results Comparing group A with group B， the high qualified embryo rate（69.4% VS 60.7%）、embryo implantation rate（40.8% VS 36.9%） and clinical pregnant rate（62.0% VS 46.0%） were all significantly diff