夜间氧疗联合噻托溴铵对老年COPD呼吸衰竭患者肺功能和生活质量影响.docVIP

夜间氧疗联合噻托溴铵对老年COPD呼吸衰竭患者肺功能和生活质量影响 　　【摘要】 目的：探讨夜间氧疗联合噻托溴铵治疗老年COPD呼吸衰竭的效果和对患者生活质量的影响。方法：80例老年COPD呼吸衰竭患者随机分组，研究组40例联合应用夜间氧疗和噻托溴铵，对照组40例单纯应用夜间氧疗，比较两组治疗后血氧情况、肺功能和生活质量。结果：研究组SaO2和mSaO2极明显高于对照组，T90极明显低于对照组（P0.01）；研究组FEV1、FVC和FEV1/FVC明显高于对照组（P0.01）；研究组患者SGRQ评分极明显低于对照组，提示患者生活质量极明显高于对照组（P0.01）。结论：夜间氧疗联合噻托溴铵治疗老年COPD呼吸衰竭具有较好疗效，可有效改善患者血氧状态和肺功能水平，同时提升生活质量。 　　【关键词】 夜间氧疗；噻托溴铵；老年COPD；呼吸衰竭；生活质量 　　Abstract：Objective: To investigate the effect of nocturnal oxygen therapy combined with tiotropium bromide in the treatment of senile respiratory failure due to COPD effect and the influence on the quality of life of the patients. Methods: 80 cases of elderly COPD patients with respiratory failure were randomly divided into two groups, study group 40 cases of combined application of oxygen therapy and Sai night ipratropium bromide, 40 cases in control group were treated by nocturnal oxygen therapy, compared two groups of patients after oxygen, pulmonary function and quality of life. Results: the study group SaO2 and mSaO2 were significantly higher than those in control group, T90 was significantly lower than the control group (P0.01); group FEV1, FVC and FEV1/FVC was significantly higher than that of the control group (P0.01); SGRQ patients in the study group were significantly lower than that of the control group, suggesting the quality of life in patients with significant high in the control group (P0.01). Conclusion: nocturnal oxygen therapy combined with tiotropium bromide in the treatment of senile COPD respiratory failure has a better curative effect, can effectively improve the oxygen status of patients and pulmonary function, and improve the quality of life. 　　Key words：nocturnal oxygen therapy, tiotropium bromide, aged COPD, respiratory failure, quality of life 　　【中图分类号】R4【文献标识码】B【文章编号】1671-8801（2014）06-0101-02 　　 　　 　　老年慢性阻塞性肺疾病（COPD）临床常见，主要因呼吸道气流受阻而引发一系列咳嗽、咳痰、呼吸不畅等不良症状，严重者可致呼吸衰竭，危急生命健康[1]。夜间睡眠低氧是COPD合并呼吸衰竭患者常见症状，不仅可引发肺心病、肺动脉高压、心律失常、神经功能损伤等，还可能因影响患者休息而进一步降低机体抵抗力，造成猝死[2]。为探