奥曲肽不同给药途径对老年急性非暴发性胰腺炎治疗效果分析.docVIP

奥曲肽不同给药途径对老年急性非暴发性胰腺炎治疗效果分析 　　【摘要】目的 比较奥曲肽静脉持续泵入与皮下注射2种给药途径治疗老年急性非暴发性胰腺炎(non-fulminant acute pancreatitis, NFAP)的疗效差异。方法将88例老年NFAP按奥曲肽给药途径不同分为奥曲肽静脉持续泵入组与皮下注射组。分别按下列指标评估：腹痛消失天数，恶心、呕吐消失天数，上腹压痛缓解天数，体温恢复天数，并发症发生率，总有效率。结果症状、体征消失时间奥曲肽持续静脉泵入组短于奥曲肽皮下注射组，P0，05；并发症发生率持续静脉泵入组为6．81％(3／44)，皮下注射组为11．36％(5／44)，P0．05；总有效率持续静脉泵入组为93．18％(41／44)，皮下注射组为81．81 (36／44)，P0．05。结论 奥曲肽治疗NFAP其静脉持续泵入较皮下注射给药疗效更好，有利于缩短病程，改善预后。 　　【关键词】急性非暴发性胰腺炎；奥曲肽；治疗 　　 　　The therapeutic efects of different given ways of Octreotide in old patients with non-fulminant acute pancreatitisCUI Li-Fang. Department of Gastroenterology, the Second Affiliated Hospital, Shandong Medical Universtiy of TCM，Jinan 250001，China 　　【Abstract】ObjectiveTo assess the difference between the two ways of subcutaneous injection and intravenous drip in which Octreotide is given to non-fulminant acute pancreatitis, (NFAP)．Methods88 old patients with NFAP were divided into two groups according to the way that Octreotide was given．Abdominal pain duration, vomiting and nausea duration, fever duration, the incidence of complications, total rate of effective were investigated and compared．ResultsIn old patients with NFAPclinic manifestation recovery time in Octreotide intravenous drip group was shorter in subcutaneous group (P0．05)；the incidence of complications was 4.54% in intravenous group and 11．36％ in subcutaneous group(P0．05); total rate of effective was 93.18% in intravenous group and 81.81% in subcutaneous group(P0．05)．ConclusionsIt is more effective that Octreotide was given to old patients with NFAP by intravenous drip than by subcutaneous injection．The way of intravenous drip can shorten the course of the disease and improve prognosis． 　　【Key word】Non-fulminant acute pancreatitis；Octreotide；Treatment 　　 　　急性胰腺炎(acute pancreatitis，AP)是指多种病因引起的胰酶激活，继以胰腺局部炎症反应为主要特征，伴或不伴有其他器官功能改变的疾病。随着生活水平的提高和饮食结构的改变，尤其是饮酒量和高脂饮食的增加，胰腺疾病在全球范围内的发病率呈逐年增高趋势。尤其是重症急性胰腺炎(SAP)，发病快，病情复杂多变，并发症多，死亡率高，已成为严重影响人类生命健康的“杀手”。生长抑素及其类似物(奥曲肽)可以通过直接抑制胰腺外分泌而发挥作用，是现有公