定量测定C反应蛋白在社区获得性肺炎诊断和疾病严重性评价中意义.docVIP

定量测定C反应蛋白在社区获得性肺炎诊断和疾病严重性评价中意义 　　【摘要】 目的 评价C反应蛋白（CRP）在社区获得性肺炎（CAP）诊治中的价值。方法 选择住院后确诊为CAP的患者32例，同时选择健康对照组20例，分别测定其血清CRP值。结果 32例CAP患者CRP值为（86．3±41．3）mg/L，20例健康对照组CRP值为（18．3±9．2）mg/L，二者比较差异有统计学意义（P0．01）。其中21例患者，占65．6%，有明确的病原学依据，最常见的病原体依次为肺炎支原体9例，占28．1%、肺炎链球菌6例，占18．8%、流感嗜血杆菌5例，占15．6%、肺炎克雷白氏杆菌1例，占3．1%。肺炎支原体、肺炎链球菌和流感嗜血杆菌肺炎患者的CRP分别为（94．8±42．9）mg/L、（91．5±43．7）mg/L、（82．3±39．7）mg/L，与健康对照组比较差异均有统计学意义（P0．01），3种病原菌肺炎患者CRP值比较差异均无统计学意义。结论 血清CRP水平可作为诊断CAP的一种特异性标记物，血清CRP水平可反映CAP的严重程度，可决定患者接受何种相应的治疗。 　　【关键词】 C反应蛋白； 社区获得性肺炎 　　 　　Detection of C-reactive protein to the diagnosis and assessment of severity of community-acquired pneumonia WU Kan-jin,ZHOU Li-rong,AN Ze-yu,et al.Department of Respiratory Medicine,Centrol Hospital of Cangzhou City,061001,China 　　【Abstract】 　　Objective To assess the usefulness of serum C-reactive protein (CRP) in the diagnosis and treatment approach of patients with community-acquiredpneumonia (CAP).Methods 32 cases of CAP confirmed were selected as the trial group, 20 cases normal donors without CAP were recruited as the control group. Serum levels of CRP were detected by Immunization than muddy France. Results Serum levels of CRP was significantly higher in patients with CAP than that in control group （P0．01）. 21 patients (65．6%) had an identifiable etiology.The most common pathogens were Mycoplasma pneumoniae (9,28．1%)，Streptococcus pneumoniae (6,18．8%)，Haemophilus influenzae(5,15．6%)，Klebsiella pneumoniae (1,3．1%). CRP of CAP caused by Mycoplasma pneumoniae、Streptococcus pneumoniae、Haemophilus influenzae were （94．8±42．9）mg/L，（91．5±43．7）mg/L and （82．3±39．7）mg/L，it were significantly higher than that in control group(P0．01). There was no significant difference of CRP in Mycoplasma pneumoniae group、Streptococcus pneumoniae group and Haemophilus influenza group. Conclusion Serum CRP level is a useful marker for establishing the diagnosis of CAP in patients. High CRP values are suggestive of severity, which may be of value in deciding about the appropria