T巴细胞介导的细胞免疫应答.pptVIP

Phagocytes with ingested microbes; microbial antigens in vesicles Infected cell with microbes in cytoplasm CD4+ effector T cells (TH1 cells) CD8+ T cells (CTL) CD8+ T cells (CTL) Macrophage activation: killing of ingested macirobes Inflammation Killing of infected cells Types of T cell-mediated immune reactions CD8+ T cells (CTL) 输出淋巴管 CD4+ effector T cells (TH1 cells) CD4+ T cells CD8+ T cells IL-12 Cell with intracellular microbes Migration of effector T cells and other leukocytes to site of antigen Induction of response Antigen recognition in lymphoid orgens T cell expansion and differentiation Differentiated effector T cells enter circulation Effector T cell encounter antigens in peripheral tissues Migration of effector T cells and other leukocytes to site of antigen Cell with intracellular microbes Differentiated effector T cells enter circulation Effector T cell encounter antigens in peripheral tissues Effector functions of T cells Macrophage activation: killing of phagocytosed microbes CTL killing of target cell Activation of effector T cells IFN-? The induction and effector phases of cell-mediated immunity naive CD4+ T cells APC Microbes Proliferation and differentiation IFN-? IFN-? LT,TNF B cell TH1 cells Fc receptor Macrophage activation (enhanced microbial killing ) Complement-binding and opsonizing antibodies Opsonization and phagocytosis Neutrophil activation (enhanced microbial killing) Effector functions of TH1 cells naive CD4+ T cells APC Microbes Proliferation and differentiation B cell TH2cells Eosinophil Mast cell degranulation Activated macrophage Suppression of macrophage activation Eosinophil activation Helminth (蠕虫) Production of IgE Production of neutralizing IgG antibodies IL-10, IL-4 IL-4 IL-5 Effector functions of TH2 cells Tc NK CTL 与 NK 细胞的比较 TCR + ， CD8 + ， CD3 + CD16 - ， CD56 - TCR - ， CD8 - ， CD3 - CD16 + ， CD56 + MHC/抗原肽提供杀伤信号 MHC分子提供杀伤抑制信号 病毒感染后期清除被病毒感染的细胞 病毒感染初期防止病毒扩散 Rolf Zinkernagle Peter Doherty Nobel Prize 1996 You won the