安脑丸联合丙戊酸钠对癫痫部分性发作疗效及认知功能影响分析.docVIP

安脑丸联合丙戊酸钠对癫痫部分性发作疗效及认知功能影响分析 　　【摘要】 目的：分析安脑丸合用丙戊酸钠治疗癫痫部分性发作的疗效及其对认知功能的影响。方法：将2013年1月-2015年1月在本院门诊就诊的80例部分性发作癫痫患者按照随机数字表法分为治疗组和对照组，每组各40例。对照组给予丙戊酸钠缓释片口服，治疗组在此基础上加用安脑丸治疗。治疗6个月后，评价两组疗效及认知功能。结果：治疗后，治疗组控制率与总有效率均高于对照组（P0.05）。两组MOCA总评分均较治疗前均有明显改善（P0.05）。治疗组对视空间/执行能力、命名、注意力、抽象能力、延迟记忆力的改善作用均优于对照组（P0.05）。结论：应用丙戊酸钠缓释片对患者认知功能有部分改善作用。安脑丸联合丙戊酸钠，不仅可以提高治疗总有效率，并对患者认知功能有明显改善作用。 　　【关键词】 癫痫部分性发作； 认知功能； 丙戊酸钠； 安脑丸 　　【Abstract】 Objective：To analyze the cognitive function and curative effect of Annao pill combined with Sodium Valproate in the treatment of partial epilepsy.Method：From January 2013 to January 2015 in our hospital，80 cases of partial epilepsy were divided into the treatment group and the control group，40 cases in each group.The control group was given Sodium Valproate sustained-release tablets，the treatment group was given Annao pill based on the control group.After treatment for 6 months，efficacy and cognitive function of two groups were evaluated.Result：After treatment，the control rate and the total effective rate of the treatment group were higher than those of the control group（P0.05）.Compared with before treatment，the total score of MOCA in two groups were significantly improved（P0.05）.The improvement of visual space/executive ability，naming，attention，abstract ability and delayed memory of the treatment group were better than those of the control group（P0.05）.Conclusion：The application of Sodium Valproate sustained-release tablets can improve the effect on cognitive function of patients.Annao pill combined with Sodium Valproate not only can improve the total efficiency of treatment，but also has significant effect on improving the cognitive function of patients. 　　【Key words】 Partial seizures of epilepsy； Cognitive function； Sodium Valproate； Annao pill 　　First-author’s address：Zhanjiang People’s Central Hospital，Zhanjiang 524037，China 　　doi：10.3969/j.issn.1674-4985.2017.25.029 　　癫痫是各种病因作用于脑，使脑细胞过度放电而出现的发作性短暂性的脑功能异常，是神经疾病里的高发病[1]。癫痫部分性发作又叫局灶性癫痫发作，它是大脑局部脑细胞出现异常放电，然