冻融胚胎移植周期内膜转化前血清高雌二醇水平不影响妊娠结局.PDF

J South Med Univ, 2018, 38(5): 601-605 doi 10.3969/j.issn. 1673-4254.2018.05.16 ·601 · 冻融胚胎移植周期内膜转化前血清高雌二醇水平不影响妊娠结冻融胚胎移植周期内膜转化前血清高雌二醇水平不影响妊娠结局局 邓 玲，陈 薪，叶德盛，陈士岭 南方医科大学南方医院妇产科生殖医学中心，广东 广州 510515 摘要：目的探讨冻融胚胎移植（FET）周期血清高雌二醇（E ）水平是否对妊娠结局有负面影响。方法 回顾性分析2017 年2 月~8 2 月于本中心行激素替代治疗（HRT）-FET 的205 个周期，根据内膜转化前E 水平分为高E 组（E 600 pg/mL ，45 例）和对照组 2 2 2 （E2≤600 pg/mL ，160例）。比较两组的基本特征和妊娠结局。结果 两组在对应取卵周期时的年龄、BMI、FET 日内膜厚度等方 面的差异无统计学意义（P0.05）。高E2 组FET 时的年龄小于对照组、雌激素使用天数大于对照组，且差异均具统计学意义（P 0.05）。两组的临床妊娠率、继续妊娠率、早期流产率、晚期流产率及活产率之间的差异无统计学意义（P0.05），且在控制FET 时的年龄和雌激素使用天数等混杂因素后，两组间妊娠结局的差异亦无统计学意义。结论 HRT-FET 周期内膜转化前血清高E2 水平不影响妊娠结局。 关键词：冻融胚胎移植；血清雌二醇；妊娠结局 Effect of serum estradiol level before progesterone administration on pregnancy outcomes of frozen-thawed embryo transfer cycles DENG Ling, CHEN Xin, YE Desheng, CHEN Shiling Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China Abstract: Objective To explore whether a high serum estradiol (E ) level before progesterone administration adversely affects 2 the pregnancy outcomes of frozen-thawed embryo transfer (FET) cycles. Methods We retrospectively analyzed 205 hormone replacement therapy (HRT)-FET cycles in our Center between February, 2017 and August, 2017. With a cutoff value of serum E2 level of 600 pg/mL before progesterone administration, the cases were divided into high E level group and control group with 2 normal E2 level, and the clinical characteristics and pregnancy outcomes were compared between the two g