TNF α和钙调蛋白激酶Ⅱ在大鼠心肌缺血后适应中的作用-内科学(心血管病)专业论文.docxVIP

独创性声明 本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的 研究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任 何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个 人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引 起的一切法律后果。 学位论文作者签名： 日期： 年 月 日 学位论文版权使用授权书 本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有 权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅 和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关 数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论 文。 本论文属于 保密□ ，在 年解密后适用本授权书。 不保密□。 （请在以上方框内打“√” ） 学位论文作者签名： 指导教师签名： 日期： 年 月 日 日期： 年 月 目 录 英文缩略词表及中文对照··············································································· 1 中文摘要············································································································ 2 Abstract 3 前 言 ··········································································································· 5 材料与方法 ····································································································· 6 结 果 ········································································································· 14 讨 论 ········································································································· 19 参考文献 ······································································································· 21 结 论 ········································································································· 23 综 述 ········································································································· 24 致 谢 ········································································································· 30 华中科技大学硕士 学位论 华 中 科 技 大 学 硕 士 学 位 论 文 PAGE 10 PAGE 10 英文缩略词表及中文对照 英文缩写 英文全称 中文全称 CaMKII Calcium/calmodulin-de pendent protein kinaseⅡ 钙离子/钙调蛋白依赖性 蛋白激酶Ⅱ SR Sarcoplasmic reticulum 肌浆网 IR Ischemia/reperfusion 缺血/再灌注 IP Ischemia-postconditio ning 缺血后适应 TNFR TNFa receptor 肿瘤坏死因子受体 RhTNFR:Fc Recombined human TNFa receptor:Fc RT-PCR Real-time quantitative polymerase chain reaction PBS phosphate buffer saline 肿瘤坏死因子受体融合 蛋白 实时定量PCR 磷酸盐缓