活血养阴法治疗糖尿病视网膜病变临床疗效及其对VEGFSDF―1水平影响.docVIP

活血养阴法治疗糖尿病视网膜病变临床疗效及其对VEGFSDF―1水平影响 　　摘要：目的探讨活血养阴法治疗糖尿病视网膜病变的临床疗效及其对VEGF、SDF-1水平的影响。方法将61例糖尿病视网膜病变患者按随机数字表法分为观察组31例和对照组30例，对照组采用西医基础治疗，治疗组在此基础上加用活血养阴法治疗。结果观察组的总有效率为81.35%，对照组的总有效率为64.91%，差异有统计意义（P0.05）。治疗后2组患者的hs-CRP、VEGF、SDF-1水平均出现了下降，差异有统计学意义，但改善程度观察组优于对照组，差异有统计意义（P0.05）。结论活血养阴法治疗糖尿病视网膜病变具有较好的临床疗效，同时可抑制hs-CRP、VEGF、SDF-1的水平，进而减轻炎症反应及血管增殖，延缓疾病的进展，提高治疗效果。 　　关键词：活血养阴；糖尿病视网膜病变；临床观察 　　中图分类号：R774.1文献标志码：B文章编号：1007-2349（2017）11-0034-03 　　【Abstract】Objective： To investigate the clinical effect of Activating Blood to Nourish Yin Method on diabetic retinopathy and its effect on VEGF and SDF-1 levels. Methods： 61 patients were randomly divided into an observation group （31 cases） and a control group （30 cases）. The control group was treated with western medicine while the treatment group was treated with Activating Blood to Nourish Yin Method besides western medicine of the control group. Results： The total effective rate of the observation group was 81.35% and the rate of the control group was 64.91%， and the difference was statistically significant （P0.05）. After treatment， the levels of hs-CRP， VEGF and SDF-1 of the two groups equally decreased， and the difference was statistically significant. But the degree of the observation group improved better than that of the control group， the difference was statistically significant （P0.05）. Conclusion： Activating Blood to Nourish Yin Method has a good clinical effect for the treatment of diabetic retinopathy and can inhibit the levels of hs-CRP， VEGF and SDF-1， and then reduce the inflammatory reaction and vascular proliferation， delay the progress of the disease and improve the therapeutic effect. 　　【Key words】Activating Blood to Nourish Yin Method， diabetic retinopathy， clinical observation 　　近年?恚?2型糖尿病的发病率逐年上升，其可影响全身各脏器及组织血管，已成为威胁健康的重要疾病[1]。其中糖尿病视网膜病变（Diabetic Retinopathy DR）为最常见的微血管并发症之一，是重要的致盲原因。其发病机制复杂，目前仍缺乏有效的治疗手段从根本上改善或阻止DR的病程进展[2]。因此亟需探讨以提高患者临床治疗效果，减少致残率的治疗方案。本科使用具有活血养阴功效的方药治疗，取得一定疗效，现报道如下。 　　1资料与方法 　　1.1一般资料收集广