小儿麻醉诱导期舒芬太尼对丙泊酚镇静作用影响探析.docVIP

小儿麻醉诱导期舒芬太尼对丙泊酚镇静作用影响探析 　　[摘要] 目的 研究小儿麻醉诱导期舒芬太尼对丙泊酚镇静作用的影响。方法 整群选取该院在2014年1―12月间收治的153例患儿的临床资料，回顾分析患儿的临床资料，根据数字随机分组法原则，将患儿分为三组，每组各51例病例。第一组取0.01 μg/（kg?min）舒芬太尼静脉输注，第二组取0.02 μg/（kg?min）舒芬太尼静脉输注，第三组单纯给予生理盐水滴注，输注后30 min后，靶控输注丙泊酚。详细记录3组患儿BIS与丙泊酚EC50值、BIS与OAA/S评分、丙泊酚EC50、LOC时间，并给予比较。结果 ①丙泊酚EC50与BIS相关系数分别为-0.81、-0.78、-0.87，两者为负相关（P0.05）。BIS与OAA/S评分相关系数分别为0.87、0.81、0.92，两者为正相关（P0.05）。②第一组、第二组的EC50、均低于第三组，对比差异有统计学意义（P0.05）。第一组、第二组的BIS、LOC时间均高于第三组，对比差异有统计学意义（P0.05）。结论 在麻醉诱导期，将丙泊酚与舒芬太尼联合使用，能够使患儿意识消失时所需丙泊酚浓度降低，协同作用非常明显，舒芬太尼的使用可以使丙泊酚镇静作用增加。 　　[关键词] 舒芬太尼；丙泊酚；镇静作用 　　[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2015）10（a）-0149-02 　　Pediatric Anesthesia Induction Period Sufentanil for Analysing the Influence of Propofol Sedation 　　LI Cai-fen 　　Department of Anesthesiology， Qujing City Maternal and Child Health Care in Yunnan Province， Qujing， Yunnan Province， 655000 China 　　[Abstract] Objective Study the induction of anesthesia in children sufentanil impact on propofol sedation. Methods Our hospital between January 2014 to December2014 were treated 153 cases of children with clinical data were retrospectively analyzed the clinical data of children. Results ① EC50 propofol and BIS correlation coefficients were -0.81， -0.78， -0.87， both negative correlation （P0.05）.BIS and OAA/S score correlation coefficients were 0.87，0.81，0.92， both positive correlation（P0.05）.②The first group， the second group of EC50， were lower than the third group， the comparison was statistically significant（P0.05）.The first group， the second group of BIS， LOC time were higher than the third group， the comparison was statistically significant （P0.05）. Conclusion In the induction of anesthesia， propofol and sufentanil in combination， can make sense of children propofol concentration required to reduce the time to disappear， synergy is very obvious， you can make use of sufentanil propofol sedation increase. 　　[Key words] Sufentanil； Propofol； Sedation 　　临床中关于舒芬太尼对丙泊酚镇静作用所产生的影响并无太多研究，为了解这种联合用药的可靠性[1]，研究整群选取了该