“解毒和营、行气祛痰”法治疗结节囊肿型痤疮的临床疗效观察-中西医结合临床专业论文.docxVIP

成都中医 成都中医药大学硕士学位论文 万方数据 万方数据 中文摘要 目的：通过对“解毒和营、行气祛痰”法治疗结节囊肿型痤疮的临床疗效观 察，探讨“化裁仙方活命饮”对结节囊肿型痤疮的疗效，并初步探讨其作用机理， 从而为临床治疗中重度痤疮提供一种安全有效的治疗方法。 方法：选取四川省中医院皮肤科门诊符合纳入标准的100例受试者，随机分 为两组。治疗组50例，予中药化裁仙方活命饮口服，对照组50例，予丹参酮胶囊 口服，两组均给予克林霉素凝胶外擦。每周复诊一次，连续治疗8周，通过对比 治疗前后评分，进行统计分析，作出疗效判定。 结果：完成临床研究者95例，临床观察显示，治疗组48例，痊愈5例，显效 11例，有效22例，无效10例，总有效率79.17%；对照组47例，痊愈3例，显效6 例，有效19例，无效19例，总有效率59.57%。经统计学分析，两组疗效差异有统 计学意义（P0.05），说明治疗组疗效明显优于对照组；在治疗2周、4周两组评 分比较，差异无统计学意义（P0.05），说明短期疗效相当；治疗6周、8周后两 组评分比较，差异有统计学意义（P0.05），说明随治疗时间的延长治疗组疗效 明显优于对照组，可以缩短疗程；对两组痊愈患者复发情况的比较，差异有统计 学意义（P0.05），说明：治疗组比对照组可明显减少复发。在临床研究过程中 两组均未出现明显不良反应。 结论：中医解毒和营、祛痰行气法（化裁仙方活命饮）治疗结节囊肿型痤疮 疗效确切，在总有效率、缩短病程、减少复发等方面均优于对照组（丹参酮胶囊 组），且无明显不良反应，具有临床推广价值。 关键词：解毒和营 行气祛痰 化裁仙方活命饮 结节囊肿型痤疮 临床观察 1 Abstract Objective: Through the clinical observation of the “ detoxication and activating blood, promoting qi and eliminating phlegm” method to treat nodules cyst acne, discuss the modified Xianfang Huoming drink’s curative effect to nodules cyst acne, and analyze it’s mechanism of action, so we can provide a safe and effective method for the treatment of Nodular and Cystic Acne. Method: We choose 100 cases fromthe dermatologyclinics of Sichuan provincechinesemedicinehospital, they are randomly divided into treatment group and control group, 50 case in each group. We give modified Xianfang Huoming drink to the treatment group, and give the DanshenTong capsule to the control group, the two groups are given clindamycin phosphate gel. The treatmentlasted for 8 weeks. The scores before and after the treatments were statistically analyzed,thus the efficacy were determined. Results: After observing the 95 cases of clinical study, the clinical test show that: In the treatment group, 5 cases heal, 11 cases have excellent effect, 22 cases have effect and 10 cases with no effect, the total effect rates are 79.17%; In the control group, 3 cases heal, 6 cases have excellent effect, 19 cases have effect and 19 cases with no effect, the total effect rates are 59.57%; After the