阿尔茨海默病治疗相关靶点探究进展.pdfVIP

Pharmacy Information 药物资讯, 2016, 5(1), 1-7 Published Online February 2016 in Hans. /journal/pi /10.12677/pi.2016.51001 Research Progress for Relative Treatment Targets in Alzheimer’s Disease Lihua Zhu, Ling He* Department of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing Jiangsu th rd th Received: Feb. 10 , 2016; accepted: Feb. 23 , 2016; published: Feb. 26 , 2016 Copyright © 2016 by authors and Hans Publishers Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). /licenses/by/4.0/ Abstract Alzheimer’s disease is neurodegenerative disease mainly characterized by cognitive impairment. Neuron and synapse loss together with neurotransmitter dysfunction have, along with Abdeposi- tion and neurofibrillary tangles, been recognized as hallmarks of AD. However, there is still no a curative treatment for this devastating disease due to complexity of the pathophysiology of the disease. This article reviews relative treatment targets in Alzheimer’s disease from the aspects of main neurotransmitter and receptors in the central nervous system. Keywords Alzheimer’s Disease, Neurotransmitter, G Protein-Coupled Receptors 阿尔茨海默病治疗相关靶点研究进展 诸丽华，何 玲* 中国药科大学，药学院，药理系，江苏 南京 收稿日期：2016年2月10 日；录用日期：2016年2月23 日；发布日期：2016年2月26 日 *通讯作者。 文章引用: 诸丽华, 何玲. 阿尔茨海默病治疗相关靶点研究进展[J]. 药物资讯, 2016, 5(1): 1-7. /10.12677/pi.2016.51001 诸丽华，何玲 摘 要 阿尔茨海默病(Alzheimer’s disease, AD)是一种以认知障碍为主要特征的退行性神经疾病。神经元和突 触损伤伴随神经递质功能异常，以及Aβ沉积和神经纤维缠结一直被认为是AD 的主要标记。但由于病因 复杂，目前针对该疾病仍无有效的治疗手段。本文将从中枢神经系统主要的神经递质及其受体方面对阿 尔茨海默病治疗相关靶点进行综述。 关键词 阿尔茨海默病，神经递质，G蛋白偶联受体 1. 引言 阿尔茨海默病(Alzheimer ’s disease, A