左旋甲状腺素片治疗妊娠期甲状腺功能低下临床效果及对妊娠结局影响评价.docVIP

左旋甲状腺素片治疗妊娠期甲状腺功能低下临床效果及对妊娠结局影响评价 　　[摘要] 目的 分析左旋甲状腺素片治疗妊娠期甲状腺功能低下的临床效果及对妊娠结局产生的影响。方法 入选该次研究中的82例妊娠期甲状腺功能低下患者均选自该院2016年3月―2017年4月期间，观察组和对照组患者分组方法为随机数字表法，每组患者例数均方便分为41例。对照组治疗方法选择基础治疗，观察组治疗方法选择左旋甲状腺素片，比较两组患者的临床疗效和妊娠结局。结果 ①观察组治疗总有效率（95.12%）高于对照组治疗总有效率（78.05%）；②观察组血清FT3、FT4高于对照组，TSH水平低于对照组；③观察组剖宫产率、低体重儿率和死亡率低于对照组；④观察组肝内胆汁淤积（0.00%）、糖代谢异常（2.44%）以及高血压（7.32%）发生率低于对照组肝内胆汁淤积（14.63%）、糖代谢异常（19.51%）以及高血压（23.49%）发生率，以上数据经比对差异有统计学意义（P0.05）。结论 妊娠期甲状腺功能低下患者采用左旋甲状腺素片进行治疗疗效确切，可将妊娠结局改善。 　　[关键词] 左旋甲状腺素片；妊娠期甲状腺功能低下；临床效果；妊娠结局 　　[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2018）02（b）-0014-03 　　[Abstract] Objective This paper tries to analyze the clinical effect of L-thyroxine tablet in the treatment of hypothyroidism during pregnancy and its effect on pregnancy outcome. Methods 82 patients with hypothyroidism during pregnancy in this hospital from March 2016 to April 2017 were convenient selected， and were divided into the observation group and the control group by digital table method， with 41 in each group. The basic treatment was given to the control group， while the observation group used L-thyroxine tablet， and then compared the clinical efficacy and pregnancy outcome between the two groups. Results ①The total effective rate（95.12%） in the observation group was higher than that in the control group （78.05%）； ② The serum levels of FT3 and FT4 in the observation group were higher than those in the control group and the TSH levels were lower than the control group； ③The cesarean section rate， low birth weight and mortality were lower than those in the control group. ④The intrahepatic cholestasis （0.00%）， abnormal glucose metabolism （2.44%） and hypertension （7.32%） in the observation group were lower than those in the control group（14.63%）， abnormal glucose metabolism （19.51%） and the incidence of hypertension（23.49%）. The above data were significantly different by comparison， with statistical significance（P0.05）. Conclusion In patients with hypothyroidism during pregnancy using L-thyroxine