布托啡诺预防舒芬太尼诱发呛咳反应临床探讨.docVIP

布托啡诺预防舒芬太尼诱发呛咳反应临床探讨 　　[摘要] 目的 探讨麻醉诱导期预先静脉注射布托啡诺对舒芬太尼诱发呛咳反应的影响。 方法 整群选取该院于2014年10月―2015年9月收治的320例手术患者资料作为研究对象，随机分为4组（每组80例）。组Ⅰ：生理盐水5 mL；组Ⅱ：地塞米松10?J；组Ⅲ：地佐辛5 mg；组Ⅳ：布托啡诺1.0 mg，均稀释至5 mL，麻醉诱导前10 s内静脉注射，5 min后4组均给予舒芬太尼0.2 μg/kg，记录出现呛咳反应的时间，强度，例数，呛咳反应时BP、P、SpO2变化。 结果 发生率：Ⅰ组22.5%；Ⅱ组2.5%；Ⅲ组1.2%；Ⅳ组2.5%。Ⅳ组的发生率明显低于Ⅰ组（P0.05）；Ⅰ组强度、例数明显高于其它组（P0.05）。 结论 布托啡诺可有效预防舒芬太尼诱发的呛咳反应，与地佐辛、地塞米松等作用相似。 　　[关键词] 布托啡诺；舒芬太尼；呛咳反应 　　[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2016）02（c）-0036-03 　　Clinical Observation of the Effect of Butorphanol on the Prevention of Cough Reaction Induced by Sulfentanyl 　　YANG Kai， LIU Bao-li， TONG Bao-feng， AI Guang-xing， JIN Ran 　　Department of Anesthesiology， Liaoning Fuxin Central Hospital， Fuxin， Liaoning Province， 123000 China 　　[Abstract] Objective To investigate the effect of intravenous administration of butorphanol in advance during anesthesia induction on the prevention of cough reaction induced by sulfentanyl. Methods The clinical data of 320 cases underwent surgery in our hospital from October 2014 to September 2015 were selected. The patients were randomly divided into 4 groups， group Ⅰ， group Ⅱ， group Ⅲ and group Ⅳ with 80 cases in each. Within 10 second before the anesthesia induction， group Ⅰ were given intravenous administration of normal saline 5 mL， group Ⅱ were given intravenous administration of dexamethasone 10 mg diluted to 5 mL， group III were given intravenous administration of dezocine 5 mg diluted to 5 mL and group Ⅳ were given intravenous administration of butorphanol 1.0 mg diluted to 5 mL， then 5 min later， sulfentanyl 0.2μg/kg was given to all the 4 groups. The time of cough reaction occurring， intensity of cough reaction， number of patients with cough reaction， the change in BP， P and SpO2 at the cough reaction in the patients were recorded. Results The incidence of cough was 22.5%， 2.5%， 1.2% and 2.5% respectively in group I， group II， group III， and group IV. The incidence of cough was much lower in group IV than that in group I（P