左炔诺孕酮宫内节育系统和安宫黄体酮在围绝经期异常子宫出血治疗中疗效观察.docVIP

左炔诺孕酮宫内节育系统和安宫黄体酮在围绝经期异常子宫出血治疗中疗效观察 　　[摘要] 目的 探讨左炔诺孕酮宫内节育系统和安宫黄体酮治疗围绝经期异常子宫出血的疗效。 方法 选取2013年 1月～2015年1月本院收治的115例围绝经期异常子宫出血患者作为研究对象，根据治疗措施的不同分为对照组（55例）和观察组（60例）。对照组给予戊酸雌二醇和安宫黄体酮，观察组给予左炔诺孕酮宫内节育系统和安宫黄体酮治疗。比较两组治疗前后的子宫内膜厚度、月经量、血红蛋白水平以及流血控制时间、止血完全时间、临床疗效。 结果 两组治疗后的子宫内膜厚度小于治疗前，月经量少与治疗前，血红蛋白水平高于治疗前，差异有统计学意义（P0.05）。观察组治疗后的子宫内膜厚度小于对照组，月经量少与对照组，血红蛋白水平高于对照组，差异有统计学意义（P0.05）。观察组的流血控制时间、止血完全时间短于对照组，差异有统计学意义（P0.05）。观察组的总有效率为98.3%，显著高于对照组的85.5%，差异有统计学意义（P0.05）。 结论 左炔诺孕酮宫内节育系统和安宫黄体酮治疗围绝经期异常子宫出血效果显著，值得临床推广应用。 　　[关键词] 左炔诺孕酮宫内节育系统；安宫黄体酮；围绝经期；异常子宫出血 　　[中图分类号] R711.52 [文献标识码] A [文章编号] 1674-4721（2016）05（b）-0060-03 　　[Abstract] Objective To explore the curative effect of levonorgestrel intrauterine system and medroxyprogesterone acetate in the treatment of abnormal uterine bleeding in the perimenopausal period. Methods 115 cases of abnormal uterine bleeding in the perimenopausal period from January 2013 to January 2015 in our hospital were selected and divided into the control group （55 cases） and the detection group （60 cases） according to different treatment methods.The control group was treated with estradiol valerate and medroxyprogesterone acetate，the observation group was treated with levonorgestrel intrauterine system and medroxyprogesterone acetate.The endometrial thickness，menstrual blood volume，the level of hemoglobin and the control bleeding time，bleeding completely time，the clinical curative effect in the two groups was compared. Results The endometrial thickness after treatment in the two groups was less than that before treatment，menstrual blood volume after treatment in the two groups was less than that before treatment，the level of hemoglobin in the two groups was higher than that before treatment，with significant difference （P 　　[Key words] Levonorgestrel intrauterine system；Medroxyprogesterone acetate；Perimenopausal period；Abnormal uterine bleeding 　　围绝经期异常子宫出血是妇女在围绝经期出现的异常子宫出血，其形成原因比较复杂，可能是由于围绝经期妇女调节生殖的神经内分泌机制失调[1-2]所致。围绝经期异常子宫出血在功能失调性子宫出血中的比例较高，约占59%，如果得不到及时、有效的治疗